Helical Chiral Pyridine N-Oxides: A New Family of Asymmetric Catalysts
Helical Chiral Pyridine N-Oxides: A New Family of Asymmetric Catalysts
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DOI：
10.1002/chem.200900607
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发表时间：
2009-01-01
影响因子：
4.3
通讯作者：
Takenaka, Norito
中科院分区：
文献类型：
--
作者：
Chen, Jinshui;Takenaka, Norito
光学活性的手性氯代烷具有生物活性和广泛的合成用途，是一类很有价值的化合物。因此，环氧化物与氯亲核试剂的开环是不对称催化的一个重要目标。本文介绍了近年来在手性吡啶N-氧化物催化剂的设计和开发方面取得的进展。
Optically active chiral alkyl chlorides are valuable compounds because of their bioactivity and versatile synthetic utility. Accordingly, the ring opening of epoxides with a chloride nucleophile stands as an important goal in asymmetric catalysis. We describe herein recent advances in the design and development of chiral pyridine N-oxide catalysts for the enantioselective synthesis of chlorohydrins.