Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses
Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses
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DOI：
10.1016/s0304-3959(00)00412-7
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发表时间：
2001-02-15
期刊：
影响因子：
7.4
通讯作者：
Lee, JH
中科院分区：
文献类型：
--
作者：
Kwon, YB;Lee, JD;Lee, JH
蜂毒（BV）传统上用于东方医学以减轻疼痛和治疗炎性疾病，如类风湿性关节炎（RA）。虽然一些研究者已经评估了BV治疗的抗炎作用，但尚未检查BV治疗对炎性疼痛的抗伤害性作用。先前在实验动物中的研究表明，BV对关节炎的治疗作用取决于给药部位。因为这种潜在的位置特异性。本研究旨在评价在慢性关节炎动物模型中，将BV注射到特定穴位（足三里）与非穴位相比的抗伤害感受效果。发现皮下BV处理（lmg/kg宠物日）显著抑制由弗氏佐剂注射引起的爪水肿。此外，BV治疗显著降低关节炎诱导的伤害性行为（即机械痛觉过敏和热痛觉过敏的伤害性评分）。BV治疗后12天至21天观察到BV的这些抗伤害性/抗炎作用。此外，BV治疗显著抑制佐剂注射后3周时腰椎脊髓中佐剂诱导的Fos表达。最后，将BV注射到足三里穴位导致对关节炎疼痛的镇痛作用显著大于BV注射到更远的非穴位。本研究表明，BV足三里穴位注射对大鼠弗氏佐剂性关节炎具有抗炎和抗伤害作用。这些发现提出了BV针灸可能是一种有前途的替代药物治疗类风湿性关节炎的长期治疗的可能性。(C)2001年国际疼痛研究协会。由Elsevier Science B. V.出版，版权所有。
Bee venom (BV) has traditionally been used in Oriental medicine to relieve pain and to treat inflammatory diseases such as rheumatoid arthritis (RA). While several investigators have evaluated the anti-inflammatory effect of BV treatment, the anti-nociceptive effect of BV treatment on inflammatory pain has not been examined. Previous studies in experimental animals suggest that the therapeutic effect of BV on arthritis is dependent on the site of administration. Because of this potential site specificity. the present study was designed to evaluate the anti-nociceptive effect of BV injections into a specific acupoint (Zusanli) compared to a non-acupoint in an animal model of chronic arthritis. Subcutaneous BV treatment (1 mg/kg pet day) was found to dramatically inhibit paw edema caused by Freund's adjuvant injection. Furthermore, BV therapy significantly reduced arthritis-induced nociceptive behaviors (i.e. the nociceptive scores for mechanical hyperalgesia and thermal hyperalgesia). These anti-nociceptive/anti-inflammatory effects of BV were observed from 12 days through 21 days post-BV treatment. In addition, BV treatment significantly suppressed adjuvant-induced Fos expression in the lumbar spinal cord at 3 weeks post-adjuvant injection. Finally, injection of BV into the Zusanli acupoint resulted in a significantly greater analgesic effect on arthritic pain as compared to BV injection in to a more distant non-acupoint. The present study demonstrates that BV injection into the Zusanli acupoint has both anti-inflammatory and anti-nociceptive effects on Freund's adjuvant-induced arthritis in rats. These findings raise the possibility that BV acupuncture may be a promising alternative medicine therapy for the long-term treatment of rheumatoid arthritis. (C) 2001 International Association for the Study of Pain. published by Elsevier Science B.V. All rights reserved.