Impact of early-life events on the susceptibility to Clostridium difficile colonisation and infection in the offspring of the pig
Impact of early-life events on the susceptibility to Clostridium difficile colonisation and infection in the offspring of the pig
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DOI：
10.1080/19490976.2018.1518554
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发表时间：
2019-01-01
期刊：
影响因子：
12.2
通讯作者：
Zentek, Juergen
中科院分区：
文献类型：
--
作者：
Grzeskowiak, Lukasz M.;Pieper, Robert;Zentek, Juergen
艰难梭菌已被证明是新生猪肠炎不受控制爆发和临床环境中抗生素相关感染的主要原因。它属于猪胃肠道早期定植者的自然群体，可在产后两周的粪便中检测到。在老年猪中，它通常保持在检测限以下。尽管粪便中可检测到高浓度的艰难梭菌及其毒素，但大多数新生猪没有表现出疾病的临床症状。到目前为止，养猪场与艰难梭菌相关的死亡率增加被认为是“自发的”，而且诱发因素大多尚未确定。艰难梭菌引起的感染是多因素的，母体因素、宿主生理学、个体发育的肠道微生物群、共同感染和环境压力可能决定了疾病发展的条件。在我们最近发表的有关新生仔猪 CDI 的工作的附录中，我们讨论了影响艰难梭菌在新生仔猪中传播和感染的“生命早期事件”。
Clostridium difficile has been documented as a major cause of uncontrolled outbreaks of enteritis in neonatal pigs and antibiotic-associated infections in clinical settings. It belongs to the natural cohort of early colonisers of the gastrointestinal tract of pigs and can be detected in faeces up to two weeks postpartum. In older pigs, it often remains under the detection limit. Most neonatal pigs show no clinical signs of disease although C. difficile and its toxins can be detected at high levels in faeces. Increased mortality rates associated with C. difficile on pig farms are, so far, considered "spontaneous" and the predisposing factors are mostly not defined. The infection caused by C. difficile is multifactorial and it is likely that the repertoire of maternal factors, host physiology, the individually developing gut microbiota, co-infections and environmental stress define the conditions for disease development. In this addendum to our recently published work on CDI in neonatal piglets, we discuss the "early-life events" that influence C. difficile spread and infection in neonatal piglets.