Effects of glucocorticoids on energy metabolism and food intake in humans
Effects of glucocorticoids on energy metabolism and food intake in humans
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DOI：
10.1152/ajpendo.1996.271.2.e317
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发表时间：
1996-08-01
影响因子：
5.1
通讯作者：
Ravussin, E
中科院分区：
文献类型：
--
作者：
Tataranni, PA;Larson, DE;Ravussin, E
在20名健康的非糖尿病白人男性志愿者中，研究了糖皮质激素给药对能量代谢和食物摄入的影响[27 +/- 5 （SD）年，72 +/- 9公斤，体脂20 +/- 7%]，随机随机分配到糖皮质激素（甲基强的松龙，甲基安非他命，n = 10）或安慰剂（placc, n = 10）治疗组。每个受试者进行两次研究：在维持体重饮食期间和在随意进食期间。通过间接量热法测量能量代谢，通过自动食物选择系统测量食物摄入量。24小时尿去甲肾上腺素排泄量（24小时NE）被用作交感神经系统活动的估计。在体重维持期间，与placc相比，静脉输注冰毒（125 mg/30 min）增加了能量消耗，口服治疗4天后，与placc相比，冰毒（40 mg/天）降低了24小时NE并增加了能量消耗。在随意进食期间，在冰毒（40 mg/天）或placc口服治疗4天后，两组的能量摄入都超过体重维持，但冰毒组的增加明显大于placc组（4,554 +/- 1,857 vs 2,867 +/- 846 kcal/天；P = 0.04）。我们的数据表明，治疗剂量的糖皮质激素主要通过增加能量摄入来诱导肥胖，这可能与糖皮质激素直接或间接作用于食欲中枢调节的能力有关。
The effect of glucocorticoid administration on energy metabolism and food intake was studied in 20 healthy, nondiabetic Caucasian male volunteers [27 +/- 5 (SD) yr, 72 +/- 9 kg, 20 +/- 7% body fat] randomly and blindly assigned to glucocorticoid (methylprednisolone, METH; n = 10) or placebo (PLAC; n = 10) treatment. Each subject was studied twice: during a weight maintenance diet and during ad libitum food intake. Energy metabolism was measured by indirect calorimetry and food intake by an automated food-selection system. Twenty-four-hour urinary norepinephrine excretion (24-h NE) was used as an estimate of sympathetic nervous system activity. During weight maintenance, METH intravenous infusion (125 mg/30 min) increased energy expenditure compared with PLAC, and after 4 days of oral therapy, METH (40 mg/day) decreased 24-h NE and increased energy expenditure compared with PLAC. During ad libitum food intake, after 4 days of METH (40 mg/day) or PLAC oral therapy, both groups increased their energy intake over weight maintenance, but the increase was significantly larger in the METH group compared with the PLAC group (4,554 +/- 1,857 vs. 2,867 +/- 846 kcal/day; P = 0.04). Our data suggest that therapeutic doses of glucocorticoids induce obesity mostly by increasing energy intake, an effect which may be related to the ability of glucocorticoids to act directly or indirectly on the central regulation of appetite.