Aberrant activity and connectivity of the posterior superior temporal sulcus during social cognition in schizophrenia
Aberrant activity and connectivity of the posterior superior temporal sulcus during social cognition in schizophrenia
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DOI：
10.1007/s00406-016-0737-y
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发表时间：
2017-10
影响因子：
4.7
通讯作者：
D. Mier;S. Eisenacher;F. Rausch;S. Englisch;M. Gerchen;V. Zamoscik;A. Meyer-Lindenberg;M. Zink;P. Kirsch
中科院分区：
文献类型：
--
作者：
D. Mier;S. Eisenacher;F. Rausch;S. Englisch;M. Gerchen;V. Zamoscik;A. Meyer-Lindenberg;M. Zink;P. Kirsch
精神分裂症与社会认知方面的重大障碍有关。这些损伤已被证明沿着后上级颞沟（pSTS）的激活改变。然而，在精神分裂症的社会认知过程中，研究pSTS的连接是稀疏的。22名精神分裂症患者和22名匹配的健康对照者完成了一项功能性磁共振成像的社会认知任务，该任务允许调查情感心理理论（ToM），情感识别和中性面部表情的处理。此外，还进行了静态测量。精神分裂症患者在社会认知任务中表现较差（组的主效应）。此外，一组由社会认知处理互动揭示了活动，以及在社会认知任务，即连接，精神分裂症患者右侧pSTS在中性面孔加工时活动增强，而在情绪识别和情感心理理论加工时活动减弱。此外，pSTS之间的低连通性揭示了情感心理理论，但不中性的面孔处理或情绪识别。在静息状态下，从右到左pSTS的连接没有组间差异。社会认知过程中右侧pSTS的这种异常活动和连接模式可能构成对情绪和意图的假阳性感知的基础，并可能导致妄想的出现和持续。
Schizophrenia is associated with significant impairments in social cognition. These impairments have been shown to go along with altered activation of the posterior superior temporal sulcus (pSTS). However, studies that investigate connectivity of pSTS during social cognition in schizophrenia are sparse. Twenty-two patients with schizophrenia and 22 matched healthy controls completed a social-cognitive task for functional magnetic resonance imaging that allows the investigation of affective Theory of Mind (ToM), emotion recognition and the processing of neutral facial expressions. Moreover, a resting-state measurement was taken. Patients with schizophrenia performed worse in the social-cognitive task (main effect of group). In addition, a group by social-cognitive processing interaction was revealed for activity, as well as for connectivity during the social-cognitive task, i.e., patients with schizophrenia showed hyperactivity of right pSTS during neutral face processing, but hypoactivity during emotion recognition and affective ToM. In addition, hypoconnectivity between right and left pSTS was revealed for affective ToM, but not for neutral face processing or emotion recognition. No group differences in connectivity from right to left pSTS occurred during resting state. This pattern of aberrant activity and connectivity of the right pSTS during social cognition might form the basis of false-positive perceptions of emotions and intentions and could contribute to the emergence and sustainment of delusions.