Poly(triol α-ketoglutarate) as biodegradable, chemoselective, and mechanically tunable elastomers
Poly(triol α-ketoglutarate) as biodegradable, chemoselective, and mechanically tunable elastomers
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DOI：
10.1021/ma8009728
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发表时间：
2008-09-09
期刊：
影响因子：
5.5
通讯作者：
Yousaf, Muhammad N.
中科院分区：
文献类型：
--
作者：
Barrett, Devin G.;Yousaf, Muhammad N.
我们报道了几种弹性体的设计基于-酮戊二酸和三醇之一的热缩聚：甘油，1,2,4-丁三醇，或1,2,6-己三醇。通过改变固化温度和固化过程的持续时间，可以获得广泛的力学性能。杨氏模量（0.1 - 657.4 MPa）、极限应力（0.2 - 30.8 MPa）和极限应变（22 - 583%）的值涵盖了许多生物材料的机械性能，增加了聚三醇-酮戊二酸酯作为生物材料的成功概率。此外，聚三醇-酮戊二酸酯系列在磷酸盐缓冲盐水溶液中水解降解最快可达2天，最长可达28天。对于聚合后修饰，重复单元包含酮，它能够与各种氧化胺末端分子反应以产生稳定的肟键。最后，通过创建用于生物特异性细胞支架支撑的微图案结构和薄膜，证明了这些弹性体的多功能性和实用性。
We report the design of several elastomers based on the thermal polycondensation of alpha-ketoglutaric acid and one of three triols: glycerol, 1,2,4-butanetriol, or 1,2,6-hexanetriol. By varying the curing temperature and the duration of the curing process, a wide range of mechanical properties was achieved. The values of the Young's modulus (0.1 - 657.4 MPa), ultimate stress (0.2 - 30.8 MPa), and ultimate strain (22 - 583%) encompass the mechanical properties of many biological materials, increasing the probability of success for the use of poly(triol alpha-ketoglutarate) as a biomaterial. Furthermore, the poly(triol alpha-ketoglutarate) series hydrolytically degraded in as fast as 2 days and as long as 28 days in phosphate-buffered saline solutions. For postpolymerization modifications, the repeat units contain ketones, which are capable of reacting with a variety of oxyamine--terminated molecules to generate stable oxime linkages. Finally, the versatility and utility of these elastomers were demonstrated by creating micropatterned structures and films for biospecific cell scaffold supports.