Within-individual stability of obesity-related biomarkers among women
Within-individual stability of obesity-related biomarkers among women
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DOI：
10.1158/1055-9965.epi-06-1089
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发表时间：
2007-06-01
影响因子：
3.8
通讯作者：
Anastos, Kathryn
中科院分区：
文献类型：
--
作者：
Kaplan, Robert C.;Ho, Gloria Y. F.;Anastos, Kathryn
目的：新的生物标志物，包括促炎细胞因子和脂肪因子正在探索作为癌症和其他肥胖相关疾病的潜在介质。将生物标志物水平与疾病结局联系起来的前瞻性研究通常在单个时间点测量生物标志物，并假设水平的个体内变化与个体间变化相比很小。然而，这一假设很少被测试。方法：本研究检查了健康年轻女性血浆脂联素、瘦素、血浆激活物抑制剂1型、肝细胞生长因子、肿瘤坏死因子α、白细胞介素6和胰岛素随时间的个体内稳定性。结果：该研究包括17名女性（9名非西班牙裔黑人，2名西班牙裔黑人，2名白色西班牙裔，4名其他指数为31.2 kg/m2，吸烟率为76%）。组内相关性（ICC）分析表明，在3年以上的重复样本中，以下各项水平具有高度至中度相关性：Alcohol n（ICC = 0.95）、肝细胞生长因子（0.91）、1型血浆激活物抑制剂（0.84）、脂联素（0.73）、胰岛素（0.62）和瘦素（0.58）。ICC较弱的促炎细胞因子，肿瘤坏死因子α（0.39）和白细胞介素6（0.47）的水平。结论：在这个人口的少数民族年轻女性的超重和吸烟的高患病率，几个肥胖相关的内分泌标志物是稳定的3年。这支持了将这些生物标志物与未来癌症发生和肥胖的其他健康后果联系起来的纵向研究的可行性。
Objective: Novel biomarkers including proinflammatory cytokines and adipokines are being explored as potential mediators of cancer and other obesity-related conditions. Prospective studies linking biomarker levels with disease outcomes often measure biomarkers at a single time point and assume that the within-individual variation in levels is small compared with the interindividual variation. However, this assumption is seldom tested.Methods: This study examined the within-individual stability over time of plasma adiponectin, resistin, leptin, plasma activator inhibitor type 1, hepatocyte growth factor, tumor necrosis factor alpha, interleukin 6, and insulin among healthy young women.Results: The study included 17 women (9 Black non-Hispanic, 2 Black Hispanic, 2 White Hispanic, and 4 other index of 31.2 kg/m(2), and 76% prevalence of smoking. Analysis of intraclass correlation (ICC) suggested high to moderate correlation over repeated samples taken over 3 years in levels of resistin (ICC = 0.95), hepatocyte growth factor (0.91), plasma activator inhibitor type 1 (0.84), adiponectin (0.73), insulin (0.62), and leptin (0.58). ICCs were weaker for levels of proinflammatory cytokines, tumor necrosis factor alpha (0.39), and interleukin 6 (0.47).Conclusion: In this population of minority young females with a high prevalence of overweight and smoking, several obesity-related endocrine markers were stable over a period of 3 years. This supports the feasibility of longitudinal studies relating these biomarkers to the future occurrence of cancer and other health consequences of obesity.