Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature.
Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature.
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高压氧暴露对实验性头颈部肿瘤生长、氧合和脉管系统的影响。
DOI：
10.1002/hed.20169
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Bernhard,EricJ
中科院分区：
文献类型：
--
作者：
Shi,Yuquan;Lee,CarolineS;Wu,Junmin;Koch,CameronJ;Thom,StephenR;Maity,Amit;Bernhard,EricJ
背景高压氧（HBO2）用于促进受照射组织的愈合，但人们仍然担心它可能促进残余肿瘤生长。方法在单剂量照射和2.4 atm绝对压力下5次/周的HBO2处理90分钟后，研究SQ20B和底特律562头颈鳞状细胞癌异种移植物的肿瘤生长。还通过免疫组织化学分析检查了HBO 2 治疗对肿瘤缺氧和脉管系统的影响。结果HBO 2 治疗在治疗间隔期间增加了肿瘤氧合，但不促进受照射或未受照射的肿瘤的生长。没有检测到肿瘤血管内皮生长因子表达或血管化的增加。结论本研究没有发现高压氧暴露引起肿瘤微环境持续变化或促进肿瘤生长的证据。 © 2005 Wiley periodicals, Inc.Head Neck27:XXX–XXX, 2005
BackgroundHyperbaric oxygen (HBO2) is used to promote healing in irradiated tissues, but concern persists about the possibility that it may promote residual tumor growth.MethodsThe tumor growth of SQ20B and Detroit 562 head and neck squamous cell carcinoma xenografts were studied after single‐dose irradiation and 5×/week HBO2treatment at 2.4 atm absolute for 90 minutes. The effect of HBO2treatment on tumor hypoxia and vasculature was also examined by immunohistochemical analysis.ResultsHBO2treatment increased tumor oxygenation during the treatment interval but did not promote the growth of either irradiated or unirradiated tumors. No increase in tumor vascular endothelial growth factor expression or vascularization was detected.ConclusionsThis study found no evidence for persistent changes in tumor microenvironment or tumor growth promotion caused by hyperbaric oxygen exposure. © 2005 Wiley Periodicals, Inc.Head Neck27:XXX–XXX, 2005