Central regulation of the cough reflex: therapeutic implications.
Central regulation of the cough reflex: therapeutic implications.
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DOI：
10.1016/j.pupt.2009.01.003
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发表时间：
2009-04
影响因子：
3.2
通讯作者：
Canning BJ
中科院分区：
文献类型：
--
作者：
Canning BJ
在包括人类在内的许多物种中，NMDA型谷氨酸受体的拮抗剂，如右美沙芬，在足够的剂量下被发现是相对安全和有效的镇咳药物。同样，现在在五个不同的物种(豚鼠、兔子、猫、狗和猪)中，神经激肽受体拮抗剂也被证明是安全有效的镇咳药。这两类药物都起到预防咳嗽的中枢作用。简要回顾了已知的咳嗽中枢编码，以及中枢镇咳药的优点。还讨论了对咳嗽和NMDA受体信号的新见解，这可能导致开发更有效的止咳药物，副作用有限，并在治疗与各种病因相关的咳嗽方面得到广泛应用。
In many species including humans, antagonists of NMDA-type glutamate receptors such as dextromethorphan, when used at sufficient doses, have been found to be relatively safe and effective antitussives. Similarly, now in five different species (guinea pigs, rabbits, cats, dogs and pigs), neurokinin receptor antagonists have also proven to be safe and effective antitussive agents. Both of these classes of drugs act centrally to prevent cough. A brief review of what is known about the central encoding of cough is presented, as are the advantages of centrally acting antitussives. Also discussed are new insights into cough and NMDA receptor signaling that may lead to the development of more effective antitussive agents with limited side effects and broad application in treating cough associated with a variety of aetiologies.
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DOI：
10.1152/ajpregu.00862.2005
发表时间：
2006-08-01
影响因子：
2.8
作者：
Canning, Brendan J.;Farmer, David G.;Mori, Nanako
通讯作者：
Mori, Nanako
影响因子：
25
作者：
Choi, YB;Tenneti, L;Lipton, SA
通讯作者：
Lipton, SA
影响因子：
5.5
作者：
BONHAM, AC;JOAD, JP
通讯作者：
JOAD, JP
影响因子：
5
作者：
Chapman, RW;House, A;Hey, JA
通讯作者：
Hey, JA
影响因子：
7.3
作者：
Childers, Wayne E., Jr.;Baudy, Reinhardt B.
通讯作者：
Baudy, Reinhardt B.