Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans
Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans
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DOI：
10.1152/ajpheart.00899.2001
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发表时间：
2002-05-01
影响因子：
4.8
通讯作者：
Crandall, CG
中科院分区：
文献类型：
--
作者：
Cui, J;Wilson, TE;Crandall, CG
本项目的目的是检验冷加压试验中压力感受器对肌肉交感神经活动（MSNA）和心率的调节发生改变的假设。将10名受试者暴露于冷加压试验，将手浸入冰水中3分钟，同时记录动脉血压、心率和MSNA。在冷加压试验的第二和第三分钟，血压降低，然后分别通过静脉推注硝普钠和盐酸苯肾上腺素升高。MSNA和舒张压之间关系的斜率在冷加压试验期间（-244.9 +/-26.3单位/次（-1））更负（P < 0.005）。与对照条件（-138.8 +/-18.6单位.搏动（-1）.mmHg（-1））相比，心率和收缩压之间的关系的斜率没有观察到显著变化。这些数据表明，压力感受器仍然能够调节MSNA和心率在冷加压试验，然而，MSNA的压力反射调制的敏感性升高，而不改变压力反射控制的心率的敏感性。
The purpose of this project was to test the hypothesis that baroreceptor modulation of muscle sympathetic nerve activity (MSNA) and heart rate is altered during the cold pressor test. Ten subjects were exposed to a cold pressor test by immersing a hand in ice water for 3 min while arterial blood pressure, heart rate, and MSNA were recorded. During the second and third minute of the cold pressor test, blood pressure was lowered and then raised by intravenous bolus infusions of sodium nitroprusside and phenylephrine HCl, respectively. The slope of the relationship between MSNA and diastolic blood pressure was more negative (P < 0.005) during the cold pressor test (-244.9 +/- 26.3 units.beat(-1) . mmHg(-1)) when compared with control conditions (-138.8 +/- 18.6 units.beat(-1).mmHg(-1)), whereas no significant change in the slope of the relationship between heart rate and systolic blood pressure was observed. These data suggest that baroreceptors remain capable of modulating MSNA and heart rate during a cold pressor test; however, the sensitivity of baroreflex modulation of MSNA is elevated without altering the sensitivity of baroreflex control of heart rate.