Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin
Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin
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DOI：
10.1073/pnas.0702000104
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发表时间：
2007-07-03
影响因子：
11.1
通讯作者：
Ogura, Toshihiko
中科院分区：
文献类型：
--
作者：
Miyasaka, Kota Y.;Kida, Yasuyuki S.;Ogura, Toshihiko
斑马鱼Csrpl是富含半胱氨酸和甘氨酸的蛋白（CSRP）家族的成员，在中胚层及其衍生物中表达。Csrpl与Dishevelled 2（Dvl2）和Diversin（Div）相互作用，其通过非经典Writ和JNK途径控制细胞形态和其他动态细胞行为。当csrpl信息被敲除时，异常的会聚延伸细胞运动被诱导，导致中线结构的严重畸形。此外，由于心脏中胚层细胞迁移的缺陷而诱导了心脏双歧杆菌。我们的数据突出Csrpl作为非经典Wnt途径的关键分子，其在组织和器官的动态形态发生运动期间协调细胞行为。
Zebrafish Csrpl is a member of the cysteine- and glycine-rich protein (CSRP) family and is expressed in the mesencloderm and its derivatives. Csrpl interacts with Dishevelled 2 (Dvl2) and Diversin (Div), which control cell morphology and other dynamic cell behaviors via the noncanonical Writ and JNK pathways. When csrpl message is knocked down, abnormal convergent extension cell movement is induced, resulting in severe deformities in midline structures. in addition, cardiac bificla is induced as a consequence of defects in cardiac mesoderm cell migration. Our data highlight Csrpl as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs.