Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys.
Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys.
复制标题
小鼠和猴子的光遗传学刺激视觉反应重组的机制。
DOI：
10.1016/j.neuron.2023.09.018
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发表时间：
2023
期刊：
影响因子：
16.2
通讯作者：
Brunel,Nicolas
中科院分区：
文献类型：
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作者：
Sanzeni,Alessandro;Palmigiano,Agostina;Nguyen,TuanH;Luo,Junxiang;Nassi,JonathanJ;Reynolds,JohnH;Histed,MarkH;Miller,KennethD;Brunel,Nicolas
光遗传学干扰神经回路的能力为研究控制回路功能的机制打开了一扇前所未有的窗口。我们分析并理论模拟了小鼠和猴子V1对视觉和光遗传输入的神经元反应。在这两个物种中，兴奋性神经元的光遗传刺激强烈调节单个神经元的活动，但对整个种群的放电率分布影响微弱或没有影响。因此，光遗传输入改变了整个网络的放电速率。小鼠和猴子反应的关键统计数据是连续的，小鼠/猴子分别占据了低/高速率区域。我们发现，神经元重组在随机连接的兴奋/抑制网络中普遍出现，只要耦合强度（循环耦合和外部输入的组合）足够强，强大的抑制反馈可以抵消平均光遗传输入。一个更现实的模型，在一个结构网络中区分调谐视觉和光遗传输入，减少了解释重组所需的耦合强度。
The ability to optogenetically perturb neural circuits opens an unprecedented window into mechanisms governing circuit function. We analyzed and theoretically modeled neuronal responses to visual and optogenetic inputs in mouse and monkey V1. In both species, optogenetic stimulation of excitatory neurons strongly modulated the activity of single neurons yet had weak or no effects on the distribution of firing rates across the population. Thus, the optogenetic inputs reshuffled firing rates across the network. Key statistics of mouse and monkey responses lay on a continuum, with mice/monkeys occupying the low-/high-rate regions, respectively. We show that neuronal reshuffling emerges generically in randomly connected excitatory/inhibitory networks, provided the coupling strength (combination of recurrent coupling and external input) is sufficient that powerful inhibitory feedback cancels the mean optogenetic input. A more realistic model, distinguishing tuned visual vs. untuned optogenetic input in a structured network, reduces the coupling strength needed to explain reshuffling.