Generation and Analysis of Mosaic Spinal Cord Organoids Derived from Mouse Embryonic Stem Cells.
Generation and Analysis of Mosaic Spinal Cord Organoids Derived from Mouse Embryonic Stem Cells.
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DOI：
10.1007/978-1-0716-1701-4_1
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发表时间：
2022
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三个中央细胞群在形态学作用，产生的细胞，分布的细胞以及对形态学反应的细胞中起着作用。利用胚胎干细胞的特性来聚集并容易地分化为神经祖细胞组织，我们描述了一种使用转基因的鼠干细胞系的方法，以单独解决这些细胞在摩西脊柱体内形态发生梯度中的贡献。
Three central cell populations play roles in morphogen action, the cells that produce, the cells that distribute, and the cells that respond to the morphogen. Taking advantage of the properties of embryonic stem cell to aggregate and readily differentiate into neural progenitor tissue, we describe an approach using genetically modified murine stem cell lines to individually address the contribution of these cells in the establishment and response to a morphogenetic gradient in mosaic spinal cord organoids.