Prodromal Motoric Cognitive Risk Syndrome and Everyday Function.
Prodromal Motoric Cognitive Risk Syndrome and Everyday Function.
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DOI：
10.3233/jad-230579
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发表时间：
2023-10
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影响因子：
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通讯作者：
Nigel L. Kravatz;Dristi Adhikari;E. Ayers;Joseph Verghese
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作者：
Nigel L. Kravatz;Dristi Adhikari;E. Ayers;Joseph Verghese
运动认知风险综合征（MCR）是一种以主观认知抱怨和步态缓慢为特征的痴呆前期综合征，与日常生活工具活动障碍有关。目前尚不清楚这些功能限制是否在痴呆症前期综合征被诊断出来之前就已经发生了。目的评估MCR前驱期患者日常生活复杂活动和辅助活动的概况。方法：我们检查了46名生活在社区的老年人（平均年龄79岁，59%的女性）的功能概况，这些老年人在基线时认知正常，在随访期间发生MCR（“MCR前”），264名老年人（平均年龄75岁，57%的女性）在随访期间保持认知完整。结果在多变量logistic回归模型中，与正常对照相比，mcr前个体在基线时复杂日常功能有更多限制（优势比1.21）。与正常对照相比，mcr前的病例在处理财务（比值比3.0）和表现爱好（比值比5.5）方面存在局限性。与对照组相比，MCR前病例从基线到MCR的复杂功能限制数量差异更大（1.2±3.0 vs 0.5±2.2,p < 0.001）。结论：MCR前驱期出现复杂日常任务的局限性，有助于风险预测。
BACKGROUND Motoric cognitive risk syndrome (MCR), a pre-dementia syndrome characterized by subjective cognitive complaints and slow gait, is associated with disability in instrumental activities of daily living. It is unknown whether these functional limitations occur even before this pre-dementia syndrome is diagnosed. OBJECTIVE To assess profiles of complex and instrumental activities of daily living in the prodromal stages of MCR. METHODS We examined functional profiles in 46 older adults (mean age 79 years, 59% women) living in the community with normal cognition at baseline who developed MCR over follow-up ('pre-MCR') with 264 older adults (mean age 75 years, 57% women) who remained cognitively intact over the follow-up period. RESULTS Pre-MCR individuals had more limitations on complex everyday function at baseline compared to normal controls in multivariable logistic regression models (odds ratio 1.21). Pre-MCR cases at baseline had limitations in handling finances (odds ratio 3.0) and performing hobbies (odds ratio 5.5) as compared to normal controls. Pre-MCR cases had a greater difference in the number of complex functional limitations from baseline to MCR compared to the difference from baseline to final visit for the controls (1.2±3.0 versus 0.5±2.2, p < 0.001). CONCLUSIONS Limitations in complex everyday tasks arise in the prodromal stages of MCR and can assist in risk prognostication.