Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory
Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory
复制标题
DOI：
10.1016/j.cell.2009.10.020
复制
发表时间：
2009-11-13
期刊：
影响因子：
64.5
通讯作者：
Inokuchi, Kaoru
中科院分区：
文献类型：
--
作者：
Kitamura, Takashi;Saitoh, Yoshito;Inokuchi, Kaoru
获得性记忆最初依赖于海马（HPC）的皮质永久记忆形成过程。内存逐渐独立于HPC的机制仍然未知。在HPC中，成年神经发生在许多哺乳动物物种中被描述，甚至在老年。使用两个小鼠模型，其中海马神经发生是物理或遗传抑制，我们表明，减少神经发生伴随着一个延长的HPC依赖期的联想恐惧记忆。自主运动增强的神经发生加快了记忆对HPC依赖性的衰减速度，而没有记忆丧失。一致的是，减少神经发生促进了大鼠海马长时程增强在体内的持久维持。这些独立的证据有力地表明，海马神经发生的水平在决定成年啮齿动物的HPC依赖性记忆期中发挥作用。这些观察结果提供了一个框架，了解大脑皮层的补充学习系统的机制。
Acquired memory initially depends on the hippocampus (HPC) for the process of cortical permanent memory formation. The mechanisms through which memory becomes progressively independent from the HPC remain unknown. In the HPC, adult neurogenesis has been described in many mammalian species, even at old ages. Using two mouse models in which hippocampal neurogenesis is physically or genetically suppressed, we show that decreased neurogenesis is accompanied by a prolonged HPC-dependent period of associative fear memory. Inversely, enhanced neurogenesis by voluntary exercise sped up the decay rate of HPC dependency of memory, without loss of memory. Consistently, decreased neurogenesis facilitated the long-lasting maintenance of rat hippocampal long-term potentiation in vivo. These independent lines of evidence strongly suggest that the level of hippocampal neurogenesis play a role in determination of the HPC-dependent period of memory in adult rodents. These observations provide a framework for understanding the mechanisms of the hippocampal-cortical complementary learning systems.