The contribution of epigenetic changes to abnormal centrosomes and genomic instability in breast cancer.
The contribution of epigenetic changes to abnormal centrosomes and genomic instability in breast cancer.
复制标题
表观遗传变化对乳腺癌异常中心体和基因组不稳定性的贡献。
DOI：
10.1023/a:1011312808421
复制
发表时间：
2001
影响因子：
2.5
通讯作者：
Salisbury,JL
中科院分区：
文献类型：
--
作者：
Salisbury,JL
中心体是细胞的主要微管组织中心，因此它在细胞骨架组织和双极有丝分裂纺锤体的形成中起重要作用。中心体缺陷，其特征在于异常的大小，数量和微管成核能力，是大多数高级别乳腺肿瘤的显著特征，并被认为是组织结构丧失和有丝分裂异常起源的可能原因，一般见于实体瘤。中心体缺陷是由于遗传改变或中心体功能的物理或化学干扰导致中心粒复制和细胞周期解偶联而产生的。中心体表现出独特的表观遗传特性，由此位置或结构信息可以通过非遗传途径通过体细胞谱系传播。由于异常的中心体功能可导致染色体不稳定，这些特性可能对恶性乳腺肿瘤的起源有重要意义。
The centrosome is the major microtubule organizing center of the cell and as such it plays an important role in cytoskeletal organization and in the formation of the bipolar mitotic spindle. Centrosome defects, characterized by abnormal size, number, and microtubule nucleation capacity, are distinguishing features of most high grade breast tumors and have been implicated as a possible cause for the loss of tissue architecture and the origin of mitotic abnormalities seen in solid tumors in general. Centrosome defects arise through uncoupling of centriole duplication and the cell cycle as a result of either genetic alterations or through physical or chemical perturbation of centrosome function. Centrosomes manifest unique epigenetic properties whereby positional or structural information can be propagated through somatic cell lineages by way of nongenetic pathways. Because aberrant centrosome function can result in chromosomal instability, these properties may have important implications for the origin of malignant breast tumors.