Adrenal Schwannoma A Rare Type of Adrenal Incidentaloma
Adrenal Schwannoma A Rare Type of Adrenal Incidentaloma
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DOI：
10.5858/arpa.2012-0291-rs
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发表时间：
2013-07-01
影响因子：
4.6
通讯作者：
Gilliland, Mary G. F.
中科院分区：
文献类型：
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作者：
Mohiuddin, Yaseen;Gilliland, Mary G. F.
肾上腺神经鞘瘤是一种罕见的肾上腺偶发瘤，是一种偶然发现的肾上腺病变，通常在影像学或尸检中发现。计算机断层扫描和磁共振成像是用来评估肾上腺病变的工具。然而，肾上腺神经鞘瘤的诊断不能仅凭影像学检查。手术切除是肾上腺神经鞘瘤的主要治疗手段，因为仅凭影像学检查无法区分神经鞘瘤和恶性肿瘤。肾上腺神经鞘瘤的组织病理学特征与其他部位的神经鞘瘤相似。传统的神经鞘瘤由交替的Antoni A区和Antoni B区以及Verocay小体组成，具有明显的显微特征，可以很容易地与其他实体区分开来。另一方面，细胞性神经鞘瘤仅由梭形细胞或Antoni A区的交叉束组成，导致广泛的鉴别诊断。辅助研究，如免疫组织化学分析和电子显微镜可以帮助提供一个具体的诊断。
Adrenal schwannoma is a rare type of adrenal incidentaloma, an adrenal lesion found incidentally, usually on imaging or autopsy. Computed tomography and magnetic resonance imaging are tools used to evaluate adrenal lesions. The diagnosis of adrenal schwannoma, however, cannot be made on imaging alone. Surgical resection is the primary means of management of adrenal schwannomas, as it is not possible to distinguish the schwannoma from malignant entities simply based on imaging. Histopathologic features of adrenal schwannomas are similar to those of schwannomas found at other sites. Conventional schwannomas, consisting of alternating Antoni A and Antoni B areas as well as Verocay bodies, have distinct microscopic features and can be readily distinguished from other entities. Cellular schwannomas, on the other hand, consist only of intersecting fascicles of spindle cells or Antoni A areas, resulting in a wide differential diagnosis. Ancillary studies such as immunohistochemical analysis and electron microscopy can help to provide a specific diagnosis.