Clinical observations of bone marrow transfusion for promoting bone marrow reconstruction after chemotherapy for AIDS-related lymphoma.
Clinical observations of bone marrow transfusion for promoting bone marrow reconstruction after chemotherapy for AIDS-related lymphoma.
复制标题
骨髓输注促进艾滋病相关淋巴瘤化疗后骨髓重建的临床观察
DOI：
10.1186/s12865-021-00399-8
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发表时间：
2021-01-28
期刊：
影响因子：
3
通讯作者：
Lu R
中科院分区：
文献类型：
--
作者：
Liu Y;Xie S;Li L;Si Y;Zhang W;Liu X;Guo L;Liu B;Lu R
This study investigates the effect of autologous bone marrow transfusion (BMT) on the reconstruction of both bone marrow and the immune system in patients with AIDS-related lymphoma (ARL). A total of 32 patients with ARL participated in this study. Among them, 16 participants were treated with conventional surgery and chemotherapy (control group) and the remaining 16 patients were treated with chemotherapy followed by autologous bone marrow transfusion via a mesenteric vein (8 patients, ABM-MVI group) or a peripheral vein (8 patients, ABM-PI group). Subsequently, peripheral blood and lymphocyte data subsets were detected and documented in all patients. Before chemotherapy, no significant difference in indicators was observed between three groups of ARL patients. Unexpectedly, 2 weeks after the end of 6 courses of chemotherapy, the ABM-MVI group, and the ABM-PI group yielded an increased level of CD8+T lymphocytes, white blood cells (WBC), and platelet (PLT) in peripheral blood in comparison to the control group. Notably, the number of CD4+T lymphocytes in the ABM-PI group was significantly higher than that in the other two groups. Additionally, no significant difference in haemoglobin levels was observed before and after chemotherapy in both the ABM-MVI and ABM-PI groups, while haemoglobin levels in the control group decreased significantly following chemotherapy. Autologous bone marrow transfusion after chemotherapy can promote the reconstruction of both bone marrow and the immune system. There was no significant difference in bone marrow recovery and reconstruction between the mesenteric vein transfusion group and the peripheral vein transfusion group. The online version contains supplementary material available at 10.1186/s12865-021-00399-8.
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DOI：
10.1097/qai.0b013e318246b862
发表时间：
2012-04-01
影响因子：
3.6
作者：
Berry, Stephen A.;Fleishman, John A.;Gebo, Kelly A.
通讯作者：
Gebo, Kelly A.
影响因子：
10.1
作者：
Schommers, Philipp;Gillor, Daniel;Hoffmann, Christian
通讯作者：
Hoffmann, Christian
影响因子：
3.8
作者：
Viard, JP;Burgard, M;Rouzioux, C
通讯作者：
Rouzioux, C
影响因子：
6.2
作者：
Benicchi, T;Ghidini, C;Imberti, L
通讯作者：
Imberti, L
影响因子：
4.1
作者：
Kitchen, Scott G.;Zack, Jerome A.
通讯作者：
Zack, Jerome A.