Intensity-modulated proton therapy for nasopharyngeal carcinoma: Decreased radiation dose to normal structures and encouraging clinical outcomes
Intensity-modulated proton therapy for nasopharyngeal carcinoma: Decreased radiation dose to normal structures and encouraging clinical outcomes
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DOI：
10.1002/hed.24341
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发表时间：
2016-04-01
影响因子：
2.9
通讯作者：
Frank, Steven J.
中科院分区：
文献类型：
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作者：
Lewis, Gary D.;Holliday, Emma B.;Frank, Steven J.
背景与调强放射治疗相比，调强质子治疗（IMPT）有可能减少危及器官（OAR）的剂量，同时保持良好的临床效果。确定了10例计划进行IMPT的鼻咽癌（NPC）患者; 9例患者还生成了基于光子的比较IMRT计划。对29个相邻OAR的平均辐射剂量进行了剂量学比较。从病历中收集疾病控制、生存率和毒性结果。29名OAR中有15名的平均剂量存在显著差异; 13名OAR接受了基于质子的计划的较低平均剂量。中位随访时间为24.5个月（范围：19-32个月）。2年局部控制率为100%，2年总生存率为88. 9%。我们观察到IMPT相比IMRT的剂量学优势。需要进一步的研究来确定这些是否转化为降低毒性和/或改善疾病控制。(C)2015 Wiley Periodicals，Inc.
Background. Intensity-modulated proton therapy (IMPT) has the potential to spare dose to organs at risk (OAR) when compared to intensity-modulated radiotherapy (IMRT) while maintaining excellent clinical outcomes.Methods. Ten patients with nasopharyngeal carcinoma (NPC) were identified for whom IMPT was planned; 9 patients also had a comparison photon-based IMRT plan generated. Dosimetric comparison of mean radiation dose to 29 adjacent OAR was performed. Disease control, survival, and toxicity outcomes were collected from the medical records.Results. There were significant differences in mean doses in 15 of the 29 OAR; 13 OAR received lower mean dose with proton-based plans. Median follow-up was 24.5 months (range, 19-32 months). Two-year locoregional control was 100% and the 2-year overall survival was 88.9%.Conclusion. We observed dosimetric advantages conferred by IMPT compared to IMRT. Further study is needed to determine if these translate into reduced toxicity and/or improved disease control. (C) 2015 Wiley Periodicals, Inc.