Disruption of the Bcl6 gene results in an impaired germinal center formation.
Disruption of the Bcl6 gene results in an impaired germinal center formation.
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Bcl6基因的破坏会导致生发中心形成受损。
DOI：
10.1084/jem.186.3.439
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发表时间：
1997-08-04
期刊：
影响因子：
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通讯作者：
Tokuhisa T
中科院分区：
文献类型：
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作者：
Fukuda T;Yoshida T;Okada S;Hatano M;Miki T;Ishibashi K;Okabe S;Koseki H;Hirosawa S;Taniguchi M;Miyasaka N;Tokuhisa T
Bcl-6基因在B细胞淋巴瘤中的染色体易位断裂点处被鉴定，其产物在生发中心（GC）B细胞中高度表达。为了研究Bcl 6在淋巴细胞中的功能，我们用Bcl 6缺陷小鼠的骨髓细胞（Bcl 6 −/−RM）重建了RAG 1缺陷小鼠。Bcl 6 −/−RM在初级淋巴组织中的增殖是正常的，并且Bcl 6 −/−RM产生对T细胞依赖性抗原特异性的初级IgG 1抗体的控制水平。然而，在这些小鼠中未发现GC。这种缺陷主要是由于B细胞的异常。因此，Bcl 6对GC B细胞的分化是必需的。
The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly in germinal center (GC) B cells. To investigate the function of Bcl6 in lymphocytes, we have generated RAG1-deficient mice reconstituted with bone marrow cells from Bcl6-deficient mice (Bcl6−/−RM). Lymphogenesis in primary lymphoid tissues of Bcl6−/−RM is normal, and Bcl6−/−RM produced control levels of primary IgG1 antibodies specific to T cell–dependent antigens. However, GCs were not found in these mice. This defect was mainly due to the abnormalities of B cells. Therefore, Bcl6 is essential for the differentiation of GC B cells.