Effect of polysaccharides from adlay seed on anti-diabetic and gut microbiota
Effect of polysaccharides from adlay seed on anti-diabetic and gut microbiota
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DOI：
10.1039/c9fo00406h
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发表时间：
2019-07-01
期刊：
影响因子：
6.1
通讯作者：
Zhang, Shi-Yu
中科院分区：
文献类型：
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作者：
Chen, Li-Chun;Fan, Zhong-Yang;Zhang, Shi-Yu
糖尿病是一种慢性代谢性疾病，其特征在于由于胰岛素抵抗和β细胞功能障碍导致的血糖水平升高。本研究旨在探讨薏仁多糖（PAS）对链脲佐菌素（STZ）诱导的糖尿病小鼠血糖和肠道菌群的影响。PAS给药可显著降低糖尿病小鼠的血糖水平和血清糖化血红蛋白（HbA 1c）水平。同样，PAS也显示总胆固醇（TC）和甘油三酯（TG）浓度降低。此外，观察到胰高血糖素样肽1（GLP-1）浓度显著增加。出乎意料的是，PAS降低了抗淀粉样蛋白β（A β（1-42））蛋白的浓度。此外，组织病理学检查表明，PAS有助于减少STZ损伤的胰腺细胞。二甲双胍处理显著降低了肠道微生物群的多样性，而PAS处理改变了微生物群的多样性和组成。总的来说，我们的研究结果表明，PAS在2型糖尿病小鼠（T2 D）中的降血糖作用可能与肠道微生物群及其代谢途径的调节有关。
Diabetes is a chronic metabolic disease characterized by elevated blood glucose levels due to insulin resistance and beta-cell dysfunction. This study aims to examine the effects of polysaccharides from adlay seeds (PAS) on hyperglycemia and gut microbiota in streptozocin (STZ)-induced diabetic mice. The administration of PAS in diabetic mice caused a significant decrease in the glucose level and serum levels of glycosylated hemoglobin (HbA1c). Similarly, PAS also showed decreased total cholesterol (TC) and triglyceride (TG) concentrations. Furthermore, a significant increase in the concentrations of glucagon-like peptide 1 (GLP-1) was observed. Unexpectedly, PAS reduced the concentrations of anti-amyloid beta (A beta(1-42)) protein. Also, histopathological examination showed that PAS contributed to the reduction of STZ-lesioned pancreatic cells. Metformin treatment significantly reduced the diversity of the gut microbiota, while PAS treatment altered the diversity and composition of the microbiota. Collectively, our findings demonstrate that the hypoglycemic effects of PAS in type-2 diabetic mice (T2D) may be associated with the regulation of the intestinal microbiota and its metabolic pathways.