In Vivo Studies of an Implantable Energy Convertor for Skeletal Muscle Powered Cardiac Assist
In Vivo Studies of an Implantable Energy Convertor for Skeletal Muscle Powered Cardiac Assist
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用于骨骼肌动力心脏辅助的植入式能量转换器的体内研究
DOI：
10.1097/00002480-199703000-00216
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发表时间：
1997
期刊：
影响因子：
4.2
通讯作者：
J. Hill
中科院分区：
文献类型：
--
作者：
S. Reichenbach;D. Farrar;E. Diao;J. Hill
一种利用骨骼肌线性收缩的机械能的装置已被植入山羊体内。这种能量转换器将肌肉的能量转化为液压能量，可以驱动各种心脏辅助装置。该装置安装在肋骨夹和钢板上，通过皮质骨螺钉固定在胸骨上。经皮液压管道将硅基工作液输送到控制肌肉负荷的外部系统。在体重60 ~ 70公斤的山羊中，将背阔肌插入物重新连接到能量转换器上。带肌内电极的电子肌肉刺激器刺激背阔肌。在急性植入物中，获得了超过150psi的液压压力。该装置的长期植入允许在有意识的未麻醉动物中进行系统评估。植入两周后，获得了超过200 psi的液压压力，每次收缩传递给外部加载系统的能量超过1j。植入6周后，装置继续自由循环。这些初步结果非常有希望，表明植入式能量转换器是可行的。能量转换器的开发是迈向无栓骨骼肌动力心脏辅助装置的重要一步。
A device that harnesses the mechanical energy of skeletal muscle contracting in a linear configuration has been implanted in goats. This energy convertor transforms muscle work to hydraulic energy that could drive a variety of cardiac assist devices. The device is mounted with a rib clamp and plate affixed to the sternum by cortical bone screws. A transcutaneous hydraulic line carries a silicon based working fluid to an external system that controls the muscle load. In 60 to 70 kg goats, the latissimus dorsi insertion was reattached to the energy convertor. A Telectronics myostimulator with intramuscular electrodes stimulated the latissimus dorsi. In acute implants, hydraulic pressures in excess of 150 psi were obtained. Chronic implantation of the device allowed system evaluation in the conscious unanesthetized animal. Two weeks after implant, hydraulic pressures in excess of 200 psi were obtained and energy transferred to the external loading system exceeded 1 J per contraction. Six weeks after implant, the device continued to cycle freely. These initial results are very promising and suggest an implantable energy convertor is feasible. Development of an energy convertor is an important step toward tether-free skeletal muscle powered cardiac assist devices.