Central prostaglandin D2 stimulates food intake via the neuropeptide Y system in mice
Central prostaglandin D2 stimulates food intake via the neuropeptide Y system in mice
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DOI：
10.1016/j.febslet.2008.01.050
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发表时间：
2008-03
期刊：
影响因子：
3.5
通讯作者：
Kousaku Ohinata;Kuniko Takagi;Kyoko Biyajima;Y. Fujiwara;S. Fukumoto;N. Eguchi;Y. Urade;A. Asakawa;M. Fujimiya;A. Inui;M. Yoshikawa
中科院分区：
文献类型：
--
作者：
Kousaku Ohinata;Kuniko Takagi;Kyoko Biyajima;Y. Fujiwara;S. Fukumoto;N. Eguchi;Y. Urade;A. Asakawa;M. Fujimiya;A. Inui;M. Yoshikawa
我们发现，前列腺素（PG）D2，在中枢神经系统中最丰富的PG，刺激小鼠脑室内给药后的食物摄入。在PGD2的两种受体亚型中，PGD2的促食欲作用可被前列腺素D受体（DP 1）的选择性激动剂所模拟，并被其拮抗剂所消除。DP1受体的拮抗剂或反义寡核苷酸的中央管理显着减少食物摄入量，体重和脂肪量。下丘脑脂质运载蛋白型PGD合成酶的mRNA水平在禁食后上调。神经肽Y（NPY）Y1受体拮抗剂也可阻断PGD 2的促食欲活性。综上所述，PGD2可能通过与NPY系统偶联的中枢DP1受体刺激摄食。
We found that prostaglandin (PG) D2, the most abundant PG in the central nervous system, stimulates food intake after intracerebroventricular administration in mice. The orexigenic effect of PGD2was mimicked by a selective agonist for the prostaglandin D receptor (DP1) receptor among two receptor subtypes for PGD2, and abolished by its antagonist. Central administration of an antagonist or antisense oligodeoxynucleotide for the DP1receptor remarkably decreased food intake, body weight and fat mass. Hypothalamic mRNA levels of lipocalin-type PGD synthase were up-regulated after fasting. The orexigenic activity of PGD2was also abolished by an antagonist for neuropeptide Y (NPY) Y1receptor. Taken together, PGD2may stimulate food intake through central DP1receptor coupled to the NPY system.