Optimizing DHA levels in piglets by lowering the linoleic acid to α-linolenic acid ratio
Optimizing DHA levels in piglets by lowering the linoleic acid to α-linolenic acid ratio
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DOI：
10.1194/jlr.m200152-jlr200
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发表时间：
2002-09-01
影响因子：
6.5
通讯作者：
Gibson, RA
中科院分区：
文献类型：
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作者：
Blank, C;Neumann, MA;Gibson, RA
我们研究了改变饲喂配方奶的 3 日龄仔猪膳食脂肪中亚油酸（LA，18:2n-6）与 α-亚麻酸（ALA，18:3n-3）比例的效果，为期 3 周。实验配方的LA-ALA比例为0.5:1、1:1、2:1、4:1和10:1。LA水平保持恒定在总脂肪的13%，而ALA水平从1.3%（10:1组）到26.8%（0.5:1组）不等。 n-3 长链 PUFA EPA 和 22:5n-3 掺入红细胞、血浆、肝脏和脑组织中与膳食 ALA 呈线性相关。相反，所有组织中 DRA 的掺入量与膳食 ALA 呈曲线关系，DHA 的最大掺入量似乎在 LA-ALA 比例 4:1 和 2:1 之间。尽管膳食 ALA 水平差异很大（分别占总脂肪的 1.3% 和 26.8%），但饲喂 10:1 和 0.5:1 的 LA-ALA 比例会导致组织中 DRA 的比例较低且相似。这些结果与足月婴儿研究相关，因为它们证实了我们早期的发现，即通过将 LA-ALA 比例从 10:1 降低至 3:1 或 4:1 对 DRA 状态产生积极影响，并且他们预测 LA-ALA 比例低于 4:1 对 DHA 状态几乎没有进一步的有益影响。
We examined the effect of altering the linoleic acid (LA, 18:2n-6) to alpha-linolenic acid (ALA, 18:3n-3) ratio in the dietary fats of 3 day old piglets fed formula for 3 weeks. The LA-ALA ratios of the experimental formulas were 0.5:1, 1:1, 2:1, 4: 1, and 10: 1. The level of LA was held constant at 13% of total fats while the level of ALA varied from 1.3% (10:1 group) to 26.8% (0.5:1 group). Incorporation of the n-3 long chain PUFA EPA and 22:5n-3 into erythrocytes, plasma, liver, and brain tissues was linearly related to dietary ALA. Conversely, incorporation of DRA into all tissues was related to dietary ALA in a curvilinear manner, with the maximum incorporation of DHA appearing to be between the LA-ALA ratios of 4:1 and 2:1. Feeding LA-ALA ratios of 10:1 and 0.5:1 resulted in lower and similar proportions of DRA in tissues despite the very different levels of dietary ALA (1.3 vs. 26.8% of total fats, respectively). These results are relevant to term infant studies in that they confirm our earlier findings of the positive effect on DRA status by lowering the LA-ALA ratio from 10:1 to 3:1 or 4:1, and they predict that ratios of LA-ALA below 4:1 would have little further beneficial effect on DHA status.