The genome of the model beetle and pest Tribolium castaneum
The genome of the model beetle and pest Tribolium castaneum
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DOI：
10.1038/nature06784
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发表时间：
2008-04-24
期刊：
影响因子：
64.8
通讯作者：
Grossmann, Daniela
中科院分区：
文献类型：
--
作者：
Richards, Stephen;Gibbs, Richard A.;Grossmann, Daniela
赤拟谷盗（Tribolium castaneum）是真核生物目中种类最丰富的一种，是研究广义昆虫发育的重要模式生物，也是储藏农产品的重要害虫。我们在这里描述它的基因组序列。这种杂食性甲虫已经进化出与不同化学环境相互作用的能力，如气味和味觉受体以及P450和其他解毒酶的大规模扩张所示。赤拟谷盗的发育比果蝇更能代表其他昆虫，这一事实反映在基因内容和功能上。例如，赤拟谷盗比果蝇保留了更多参与细胞间通讯的祖先基因，其中一些基因在短胚发育中对轴向伸长至关重要的生长区中表达。系统性RNA干扰T. castaneum的功能与秀丽隐杆线虫中的功能不同，但仍然提供了类似的能力，用于阐明基因功能和鉴定选择性昆虫控制的靶标。
Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell - cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short- germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.