Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain
Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain
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DOI：
10.1016/j.molbrainres.2003.11.020
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发表时间：
2004-03-17
期刊：
影响因子：
--
通讯作者：
Tohyama, M
中科院分区：
文献类型：
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作者：
Honda, A;Miyoshi, K;Tohyama, M
成束和延伸蛋白zeta-1（FEZ 1）是秀丽隐杆线虫（Caelophabditis elegans）中与轴突生长和成束有关的蛋白质的哺乳动物同源物。最近，我们报道了FEZ 1与精神分裂症候选基因的产物Disrupted-In-Schizophrenia 1（DISC 1）相互作用，并且这些蛋白质之间的相互作用在神经突生长中起作用。这次，我们研究了FEZ 1和DISC 1的表达在发育中的大鼠脑使用原位杂交。FEZ 1和DISC 1均表现出高水平的表达，尤其是在发育中的海马神经元中。这些发现表明FEZ 1和DISC 1可能参与海马神经回路的形成。(C)2004 Elsevier B. V.保留所有权利。
Fasciculation and elongation protein zeta-1 (FEZ1) is a mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth and fasciculation. Recently, we reported that FEZ1 interacts with Disrupted-In-Schizophrenia 1 (DISC1), a product of the candidate gene for schizophrenia, and that the interaction between these proteins has a role in neurite outgrowth. This time, we investigated the expression of FEZ1 and DISC1 in the developing rat brain using in situ hybridization. Both FEZ1 and DISC1 showed high levels of expression, especially in developing hippocampal neurons. These findings suggest the potential involvement of FEZ1 and DISC1 in the formation of hippocampal neural circuits. (C) 2004 Elsevier B.V. All rights reserved.