Frontal Atrophy and Executive Dysfunction Relate to Complex Numbers Impairment in Progressive Supranuclear Palsy.
Frontal Atrophy and Executive Dysfunction Relate to Complex Numbers Impairment in Progressive Supranuclear Palsy.
复制标题
DOI：
10.3233/jad-215327
复制
发表时间：
2022
影响因子：
4
通讯作者：
Cousins, Katheryn A. Q.
中科院分区：
文献类型：
--
作者：
Howard, Erica;Ballinger, Samantha;Kinney, Nikolas G.;Balgenorth, Yvonne;Ehrhardt, Annabess;Phillips, Jeffrey S.;Irwin, David J.;Grossman, Murray;Cousins, Katheryn A. Q.
关键词：
先前的研究发现了帕金森综合征（PS）的一系列数字障碍，但主要集中在视觉空间障碍如何影响基本数字处理（例如，大小判断，分块）的缺陷。区分这些基本功能和日常任务中经常使用的更复杂的数字处理可能有助于阐明PS中数字缺陷的神经认知和神经解剖学基础。为了测试PS中复杂数字处理的神经认知和神经解剖学相关性，我们评估了进行性核上性麻痹（PSP）和路易体谱障碍（LBSD）的数字能力、神经心理表现和皮层厚度。56例患者（LBSD = 35; PSP = 21）完成了数字测试，包括基本和复杂的数字任务。简易精神状态测试（MMSE）、字母流畅性（LF）和线方向判断（JOLO）分别评估了全球、执行和视觉空间功能。Mann-Whitney U测试比较了神经心理测试和秩变换协方差分析（ANCOVA），在调整人口变量的情况下比较了组间的数字表现。斯皮尔曼和部分相关性将数字的表现与神经心理学任务联系起来。神经影像学评估了疾病组和人口统计学匹配的健康对照组的皮质厚度。PSP的复数表现不如LBSD (F = 6.06, p = 0.02)，但基本数字表现相似（F = 0.38, p > 0.1）， MMSE和性别共变。在所有综合征中，受损的复数表现与较差的LF （rho = 0.34, p = 0.01）有关，但与JOLO无关（rho = 0.23, p > 0.05）。成像显示，与对照组相比，PSP患者的额叶明显萎缩，这与较差的LF和复数表现有关。与LBSD相比，PSP在复数处理方面表现出选择性损伤。这种复杂的数字缺陷可能与执行功能障碍和额叶萎缩有关。
Previous research finds a range of numbers impairments in Parkinsonian syndromes (PS), but has largely focused on how visuospatial impairments impact deficits in basic numerical processes (e.g., magnitude judgments, chunking). Differentiation between these basic functions and more complex numerical processes often utilized in everyday tasks may help elucidate neurocognitive and neuroanatomic bases of numbers deficits in PS. To test neurocognitive and neuroanatomic correlates of complex numerical processing in PS, we assessed number abilities, neuropsychological performance, and cortical thickness in progressive supranuclear palsy (PSP) and Lewy body spectrum disorders (LBSD). Fifty-six patients (LBSD = 35; PSP = 21) completed a Numbers Battery, including basic and complex numerical tasks. The Mini-Mental State Exam (MMSE), letter fluency (LF), and Judgment of Line Orientation (JOLO) assessed global, executive, and visuospatial functioning respectively. Mann-Whitney U tests compared neuropsychological testing and rank-transformed analysis of covariance (ANCOVA) compared numbers performance between groups while adjusting for demographic variables. Spearman’s and partial correlations related numbers performance to neuropsychological tasks. Neuroimaging assessed cortical thickness in disease groups and demographically-matched healthy controls. PSP had worse complex numbers performance than LBSD (F = 6.06, p = 0.02) but similar basic numbers performance (F = 0.38, p > 0.1), covarying for MMSE and sex. Across syndromes, impaired complex numbers performance was linked to poor LF (rho = 0.34, p = 0.01) but not JOLO (rho = 0.23, p > 0.05). Imaging revealed significant frontal atrophy in PSP compared to controls, which was associated with worse LF and complex numbers performance. PSP demonstrated selective impairments in complex numbers processing compared to LBSD. This complex numerical deficit may relate to executive dysfunction and frontal atrophy.
影响因子：
2.4
作者：
Koss, Shira;Clark, Robin;Vesely, Luisa;Weinstein, Jessica;Powers, Chivon;Richmond, Lauren;Farag, Christine;Gross, Rachel;Liang, Tsao-Wei;Grossman, Murray
通讯作者：
Grossman, Murray
影响因子：
2.6
作者：
Spotorno, Nicola;McMillan, Corey T.;Powers, John P.;Clark, Robin;Grossman, Murray
通讯作者：
Grossman, Murray