Membrane domain formation induced by binding/unbinding of curvature-inducing molecules on both membrane surfaces
Membrane domain formation induced by binding/unbinding of curvature-inducing molecules on both membrane surfaces
复制标题
通过两个膜表面上的曲率诱导分子的结合/解除结合诱导膜域形成
DOI：
10.1039/d2sm01536f
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发表时间：
2023
期刊：
影响因子：
3.4
通讯作者：
Noguchi Hiroshi
中科院分区：
文献类型：
--
作者：
Noguchi Hiroshi
曲率诱导分子，如外周或跨膜蛋白质和锥形表面活性剂，域的形成进行了研究，在热平衡和非平衡稳态使用无网格膜模拟。这些分子可以结合到双层膜的两个表面，也可以通过触发器移动到相对的小叶。在对称条件下的两个小叶，膜域形成棋盘图案，除了条纹和斑点图案。未绑定的膜稳定棋盘格的顶点。在非对称条件下，畴形成kagome点阵和线状结构。在非平衡稳态中，结合分子在上下解之间的流动可以通过触发器发生。
The domain formation of curvature-inducing molecules, such as peripheral or transmembrane proteins and conical surfactants, is studied in thermal equilibrium and nonequilibrium steady states using meshless membrane simulations. These molecules can bind to both surfaces of a bilayer membrane and also move to the opposite leaflet by a flip–flop. Under symmetric conditions for the two leaflets, the membrane domains form checkerboard patterns in addition to striped and spot patterns. The unbound membrane stabilizes the vertices of the checkerboard. Under asymmetric conditions, the domains form kagome-lattice and thread-like patterns. In the nonequilibrium steady states, a flow of the binding molecules between the upper and lower solutions can occur via flip–flop.