Mitochondrial homeostasis in adipose tissue remodeling.
Mitochondrial homeostasis in adipose tissue remodeling.
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DOI：
10.1126/scisignal.aai9248
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发表时间：
2017-02-28
影响因子：
7.3
通讯作者：
Kajimura S
中科院分区：
文献类型：
--
作者：
Altshuler-Keylin S;Kajimura S
线粒体的动态平衡是由线粒体生物发生和降解之间的平衡来调节的。新出现的证据表明，有丝分裂是一种选择性的自噬形式，可以降解线粒体，在线粒体丰富的细胞(如棕色和米色脂肪细胞)的生理学和病理生理学中发挥关键作用。该综述讨论了自噬和有丝分裂吞噬在细胞发育、维持和代谢器官功能中的作用，包括脂肪组织、肝脏和胰腺。更好地了解有丝分裂和能量代谢之间的分子联系将有助于确定治疗肥胖症和肥胖症相关疾病的有希望的靶点。
Mitochondrial homeostasis is regulated by a balance between mitochondrial biogenesis and degradation. Emerging evidence suggests that mitophagy, a selective form of autophagy that degrades mitochondria, plays a key role in the physiology and pathophysiology of mitochondria-enriched cells, such as brown and beige adipocytes. This review discusses findings regarding the roles of autophagy and mitophagy in cellular development, maintenance, and functions of metabolic organs, including adipose tissue, liver, and pancreas. A better understanding of the molecular links between mitophagy and energy metabolism will help to identify promising targets for the treatment of obesity and obesity-associated disorders.