Caldesmon: binding to actin and myosin and effects on elementary steps in the ATPase cycle.
Caldesmon: binding to actin and myosin and effects on elementary steps in the ATPase cycle.
复制标题
Caldesmon：与肌动蛋白和肌球蛋白结合并对 ATP 酶循环中的基本步骤产生影响。
DOI：
10.1046/j.1365-201x.1998.00449.x
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Chen,YD
中科院分区：
文献类型：
--
作者：
Chalovich,JM;Sen,A;Resetar,A;Leinweber,B;Fredricksen,RS;Lu,F;Chen,YD
肌动蛋白结合蛋白caldesmon抑制肌球蛋白ATP酶活性的肌动蛋白激活。钙调素可以抑制ATP水解循环中的步骤包括：（1）肌球蛋白与肌动蛋白的结合，（2）任何两个肌动蛋白-肌球蛋白状态之间的转换和（3）肌动蛋白的非活性和活性状态之间的分布。对这些可能性的分析是复杂的，因为钙调蛋白同时与肌球蛋白和肌动蛋白结合，而且每个钙调蛋白分子与几个肌动蛋白单体结合。本文回顾了这些相互作用的分析程序，并总结了目前的信息，钙调蛋白与肌动蛋白和肌球蛋白的相互作用的稳定性和动力学。钙调素对肌动球蛋白ATP酶周期内的转换可能产生的影响也进行了讨论。
The actin binding protein caldesmon inhibits the actin‐activation of myosin ATPase activity. The steps in the cycle of ATP hydrolysis that caldesmon could inhibit include: (1) the binding of myosin to actin, (2) the transition between any two actin–myosin states and (3) the distribution between inactive and active states of actin. The analysis of these possibilities is complicated because caldesmon binds to both myosin and actin and because each caldesmon molecule binds to several actin monomers. This paper reviews procedures for analysing these interactions and summarizes current information on the stability and dynamics of the interaction of caldesmon with actin and myosin. Possible effects of caldesmon on transitions within the ATPase cycle of actomyosin are also discussed.