POST CARDIAC INJURY SYNDROME AND AN INCREASED HUMORAL IMMUNE-RESPONSE AGAINST THE MAJOR CONTRACTILE PROTEINS (ACTIN AND MYOSIN)
POST CARDIAC INJURY SYNDROME AND AN INCREASED HUMORAL IMMUNE-RESPONSE AGAINST THE MAJOR CONTRACTILE PROTEINS (ACTIN AND MYOSIN)
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DOI：
10.1016/0002-9149(85)91024-0
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发表时间：
1985-01-01
影响因子：
2.8
通讯作者：
CLEMENT, D
中科院分区：
文献类型：
--
作者：
DESCHEERDER, I;VANDEKERCKHOVE, J;CLEMENT, D
为了更好地了解心脏损伤后综合征（PCIS）的发病机制，对两种心脏损伤模型进行了研究。对129例心脏手术患者和80例急性心肌梗死（AMI）患者进行前瞻性随访，测定抗心脏抗体（AHA）、抗肌动蛋白抗体（AAA）和抗肌球蛋白抗体（AMA）水平。在手术组中，27名患者（21%）发生PCIS，36名患者（28%）发生不完全PCIS。在AMI组中，所有患者均未发生PCIS，但11例患者（14%）发生了不完全PCIS（p < 0.001）。当分析AHA和抗收缩蛋白抗体时，手术组显示出显著高于AMI组的体液免疫应答。心脏手术后，59例（46%）患者发生AHA，33例（26%）患者发生AAA，49例（38%）患者发生AMA; AMI组中，16例（20%）患者发生AHA，7例（9%）患者发生AAA，13例（16%）患者发生AMA。这些研究表明，PCIS临床分类和抗心脏收缩蛋白的自身抗体之间存在显著相关性。
To better understand the pathogenesis of the post-cardiac injury syndrome (PCIS) 2 models of cardiac injury were studied. One hundred twenty-nine patients who underwent cardiac surgery and 80 patients with acute myocardial infarction (AMI) were prospectively followed and the levels of anti-heart antibodies (AHA), anti-actin antibodies (AAA) and anti-myosin antibodies (AMA) were determined. In the surgical group, PCIS developed in 27 patients (21%) and incomplete PCIS in 36 (28%). In the AMI group, PCIS did not develop in any patient, but incomplete PCIS developed in 11 patients (14%) (p < 0.001). The surgical group showed a significantly higher humoral immune response than the AMI group when analyzed for AHA and anti-contractile protein antibodies. After cardiac surgery, AHA developed in 59 patients (46%), AAA developed in 33 (26%) and AMA developed in 49 (38%); in the AMI group, significant levels of AHA, AAA and AMA developed in 16 (20%), 7 (9%) and 13 patients (16%), respectively. These studies show a significant correlation between the PCIS clinical classification and auto-antibodies raised against heart contractile proteins.