Noyori's Ts‐DPEN Ligand: Simple yet Effective Catalyst for the Highly Enantioselective Michael Addition of Acetone to Nitroalkenes
Noyori's Ts‐DPEN Ligand: Simple yet Effective Catalyst for the Highly Enantioselective Michael Addition of Acetone to Nitroalkenes
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DOI：
10.1002/ejoc.200901509
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发表时间：
2010-04
影响因子：
2.8
通讯作者：
Lin Peng;Xiao‐Ying Xu;Liang-Liang Wang-Liang;Jun Huang;Jian-Fei Bai;Qing‐Chun Huang;Li‐Xin Wang
中科院分区：
文献类型：
--
作者：
Lin Peng;Xiao‐Ying Xu;Liang-Liang Wang-Liang;Jun Huang;Jian-Fei Bai;Qing‐Chun Huang;Li‐Xin Wang
在简单手性伯胺双功能催化剂（如Noyori的Ts-DPEN配体）的催化下，丙酮与对苯二甲酸进行了高对映选择性的Michael加成反应，收率（84- 99%）和对映选择性（93 - 98% ee）优异。
Highly enantioselective Michael addition of acetone to a variety of nitroalkenes promoted by simple chiral primary amine bifunctional catalysts (e.g., Noyori's Ts-DPEN ligand) together with terephthalic acid in excellent yields (84-99 %) and enantioselectivities (93―98 % ee) is reported.