INFLAMMATORY VASCULITIS IN MULTIPLE-SCLEROSIS
INFLAMMATORY VASCULITIS IN MULTIPLE-SCLEROSIS
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DOI：
10.1016/0022-510x(85)90139-x
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发表时间：
1985-01-01
影响因子：
4.4
通讯作者：
VIPOND, H
中科院分区：
文献类型：
--
作者：
ADAMS, CWM;POSTON, RN;VIPOND, H
对25例多发性硬化患者的斑块或病变区(52个)进行了检查。在这些疾病中，24人表现出急性特征；其余的性质较慢性。急性病变表现为淋巴细胞渗出(79%)、纤维蛋白渗出(63%)、淋巴细胞性脑膜炎(50%)和静脉炎(58%)。慢性病变中淋巴细胞渗出仅占21%，纤维蛋白渗出占11%，无脑膜炎，机化性脉管炎占29%，静脉壁纤维化占36%。在急性病变中发现纤维素炎性渗出物是多发性硬化症的新发现。同样，观察到局限于静脉壁的炎性浸润物(通常出现在距离斑块较远的地方)以前没有记录在这种疾病中。相比之下，慢性病变显示相对较少的纤维蛋白，但受累静脉壁有相当大的修复性增厚。这些证据为多发性硬化症的炎症过程提供了新的体液和细胞证据，该过程先于脱髓鞘过程或与脱髓鞘过程不直接相关。
Plaque or lesion areas (52) were examined from 25 cases of multiple sclerosis. Of these, 24 showed acute features; the rest were more chronic in nature. The acute lesions showed lymphocytic infiltration (79%), fibrinous exudation (63%), lymphocytic meningitis (50%) and venulitis (58%). Of the chronic lesions, there were only 21% with lymphocytic infiltration, 11% with fibrinous exudates, none with meningitis, 29% with organizing endovenulitis and 36% with fibrosed vein walls. The finding of a fibrinous inflammatory exudate in the acute lesion is a new observation in multiple sclerosis. Likewise, the observation of an inflammatory infiltrate confined to the vein wall (and often present at a distance from the plaque) has not been previously recorded in the disease. The chronic lesion, by contrast, showed relatively little fibrin, but there was considerable reparative thickening of the walls of the involved veins. The evidence provides new humoral and cellular evidence of an inflammatory process in multiple sclerosis which precedes or is not directly associated with the demyelinating process.