18F-FDG PET/CT for the quantification of inflammation in large carotid artery plaques
18F-FDG PET/CT for the quantification of inflammation in large carotid artery plaques
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DOI：
10.1007/s12350-017-1121-7
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发表时间：
2019-06-01
影响因子：
2.4
通讯作者：
Revheim, Mona-Elisabeth
中科院分区：
文献类型：
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作者：
Johnsrud, Kjersti;Skagen, Karolina;Revheim, Mona-Elisabeth
背景：目前对动脉粥样硬化炎症中F-18-FDG摄取的定量方法尚无共识。在这项研究中，我们探索了量化颈动脉粥样硬化斑块中F-18-FDG摄取的不同方法，并将摄取值与炎症的组织学评估联系起来。方法与结果对44例70%颈内动脉粥样硬化性狭窄患者行F-18-FDG PET/CT检查。收集所有含斑块切片的最大标准化摄取值（SUVmax）。计算经过和不经过血液背景校正(通过减法（cSUV）或分割（目标与背景比（TBR））的多个切片的单最高SUVmax和平均值。动脉内膜切除术后对30个斑块进行组织学评估。CT上斑块长度为6-32mm。未校正的suv对斑块的F-18-FDG摄取为1.15-2.66，tbr为1.16-3.19，csuv为0.20-1.79。不同摄取值之间存在显著相关性(r=0.57 ~ 0.99， P
BackgroundThere is currently no consensus on the methodology for quantification of F-18-FDG uptake in inflammation in atherosclerosis. In this study, we explore different methods for quantification of F-18-FDG uptake in carotid atherosclerotic plaques and correlate the uptake values to histological assessments of inflammation.Methods and ResultsForty-four patients with atherosclerotic stenosis 70% of the internal carotid artery underwent F-18-FDG PET/CT. Maximum standardized uptake values (SUVmax) from all plaque-containing slices were collected. SUVmax for the single highest and the mean of multiple slices with and without blood background correction (by subtraction (cSUV) or by division (target-to-background ratio (TBR)) were calculated. Following endarterectomy 30 plaques were assessed histologically. The length of the plaques at CT was 6-32mm. The F-18-FDG uptake in the plaques was 1.15-2.66 for uncorrected SUVs, 1.16-3.19 for TBRs, and 0.20-1.79 for cSUVs. There were significant correlations between the different uptake values (r=0.57-0.99, P