Cocaine and metabolites urinary excretion after controlled smoked administration
Cocaine and metabolites urinary excretion after controlled smoked administration
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DOI：
10.1093/jat/31.8.462
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发表时间：
2007-10-01
影响因子：
2.5
通讯作者：
Paul, Buddha D.
中科院分区：
文献类型：
--
作者：
Huestis, Marilyn A.;Darwin, W. David;Paul, Buddha D.
了解可卡因和代谢物的尿液排泄吸烟后是重要的尿液检测结果的解释在司法，工作场所和治疗环境。在国家药物滥用研究所批准的安全研究单位的研究中，6名受试者使用精确剂量输送装置吸食安慰剂，10，20和40 mg可卡因，6名不同的受试者在玻璃管中吸食42 mg可卡因。收集长达7天的尿液标本（n= 700），并通过气相色谱-质谱法分析可卡因（COC）、苯甲酰芽子碱（BE）、芽子碱甲酯（EME）、间羟基苯甲酰芽子碱（mOHBE）、对羟基苯甲酰芽子碱（pOHBE）、去甲苯甲酰芽子碱（NBE）和芽子碱（EC）。40 mg精确递送剂量的结果（平均值± SE）如下：所有分析物的平均Cmax随剂量增加而线性增加。Tmax无剂量依赖性。部分受试者在2 h内检出所有代谢产物。EC浓度显着更高后，吸可卡因在一个精确的交付线圈相比，玻璃“裂纹”管。
Understanding cocaine and metabolites urinary excretion following smoking is important for interpretation of urine test results in judicial, workplace and treatment settings. In National Institute on Drug Abuse approved studies on a secure research unit, six subjects smoked placebo, 10, 20, and 40 mg cocaine with a precise dose delivery device and six different subjects smoked 42 mg cocaine in a glass pipe. Urine specimens (n= 700) were collected for up to seven days and analyzed for cocaine (COC), benzoylecgonine (BE), ecgonine methylester (EME), m-hydroxybenzoylecgonine (mOHBE), p-hydroxybenzoylecgonine (pOHBE), norbenzoylecgonine (NBE), and ecgonine (EC) by gas chromatography-mass spectrometry. Results (mean ± SE) for the 40-mg precise delivery doses are as follows:Mean Cmaxfor all analytes linearly increased with increasing dose. Tmaxwas not dose-dependent. All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass “crack” pipe.