Regulatory T lymphocytes in myocardial infarction: A promising new therapeutic target.
Regulatory T lymphocytes in myocardial infarction: A promising new therapeutic target.
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DOI：
10.1016/j.ijcard.2015.11.078
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发表时间：
2016-01
影响因子：
3.5
通讯作者：
Yaping Wang;Yao Xie;Hong Ma;Sheng'an Su;Yi-dong Wang;Jian-an Wang;Mei-xiang Xiang
中科院分区：
文献类型：
--
作者：
Yaping Wang;Yao Xie;Hong Ma;Sheng'an Su;Yi-dong Wang;Jian-an Wang;Mei-xiang Xiang
心肌梗死（MI）是主要的死亡原因之一，尤其是在发达国家。尽管早期心肌再灌注治疗的出现有助于降低MI患者的死亡率，但心肌缺血再灌注损伤和修复过程中的不良重构仍然是损害心功能和导致预后不良的主要因素。过度的炎症反应和免疫反应在MI的整个过程中起着至关重要的作用。调节性T淋巴细胞以免疫抑制能力为特征，与许多免疫相关疾病相关。最近的研究已经证明了调节性T细胞在MI中的保护作用，这主要是通过调节炎症和免疫反应来实现的。本文综述了调节性T淋巴细胞在心肌梗死发病、缺血再灌注损伤以及梗死后心脏愈合和重塑中的作用。
Myocardial infarction (MI) is one of the leading causes of death especially in developed countries. Although the advent of early myocardial reperfusion therapy contributes to decreasing the mortality of patients with MI, cardiac ischemia-reperfusion injury and adverse remodeling during the repair process still remain the major factors impairing cardiac function and resulting in unsatisfactory prognosis. Excessive inflammation and immune responses play a crucial role during the whole process of MI. Regulatory T lymphocytes, characterized by immunosuppressive capacity, are associated with many immune-related diseases. Recent studies have proven a protective role of regulatory T cells in MI, which is mainly achieved by modulating inflammation and immune responses. In this review, we will summarize current knowledge of regulatory T lymphocytes, and highlight their roles in the onset of MI, ischemia-reperfusion injury, as well as post-infarct cardiac healing and remodeling.