Structural Concept of Nitroxide As a Lipid Peroxidation Inhibitor
Structural Concept of Nitroxide As a Lipid Peroxidation Inhibitor
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氮氧化物作为脂质过氧化抑制剂的结构概念
DOI：
10.1021/jo200361p
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
et al
中科院分区：
文献类型：
--
作者：
Yamasaki T;et al
氮氧自由基对脂质过氧化有抗氧化作用，但空间因素的影响尚不清楚。我们在N-O部分的α-位合成了烷基取代的氮氧自由基，以增强亲脂性和体积效应。使用硫代巴比妥酸反应物质（TBARS）测定，氮氧自由基的IC 50和亲脂性（logPo/w）之间具有良好的相关性。此外，TBARS测定的抑制作用取决于烷基的数量和长度，尽管氮氧自由基具有几乎相同的亲脂性。
Nitroxides have antioxidative activities toward lipid peroxidation, but the influence of steric factors is not known. We synthesized alkyl-substituted nitroxides at the α-position of the N–O moiety to enhance lipophilicity and the bulk effect. There was good correlation between the IC50and lipophilicity (logPo/w) of nitroxides with use of the thiobarbituric acid-reactive substances (TBARS) assay. Furthermore, an inhibitory effect on the TBARS assay was dependent upon the number and length of alkyl groups, though nitroxides had almost identical lipophilicity.