Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning
Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning
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DOI：
10.1101/lm.48803
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发表时间：
2003-05-01
影响因子：
2
通讯作者：
Abel, T
中科院分区：
文献类型：
--
作者：
Graves, LA;Heller, EA;Abel, T
许多动物和人类的行为和电生理学研究表明，睡眠和昼夜节律会影响记忆巩固。在啮齿类动物中，海马依赖性记忆可能对训练后的睡眠剥夺特别敏感，因为训练后快速眼动睡眠剥夺会损害莫里斯水迷宫中的空间记忆。然而，莫里斯水迷宫中的空间学习需要多次训练试验和性能，因为到达隐藏平台的时间不仅受到空间学习的影响，还受到程序学习的影响。为了确定睡眠对于巩固单次试验、海马依赖性任务是否很重要，我们在进行情境和暗示恐惧调节训练后，让动物睡眠不足 0-5 和 5-10 小时。我们发现，这项任务训练后 0-5 小时的睡眠剥夺会损害情境恐惧调节的记忆巩固，而训练后 5-10 小时的睡眠剥夺则没有效果。任何一个时间点的睡眠剥夺对暗示恐惧调节（一项独立于海马体的任务）都没有影响。先前的研究已经确定，当睡眠剥夺有效时同时给予蛋白激酶A和蛋白质合成抑制剂时，恐惧调理的记忆巩固会受到损害，这表明睡眠剥夺可能通过改变这些记忆存储的分子机制来发挥作用。
Many behavioral and electrophysiological studies in animals and humans have suggested that sleep and circadian rhythms influence memory consolidation. In rodents, hippocampus-dependent memory may be particularly sensitive to sleep deprivation after training, as spatial memory in the Morris water maze is impaired by rapid eye movement sleep deprivation following training. Spatial learning in the Morris water maze, however, requires multiple training trials and performance, as measured by time to reach the hidden platform is influenced by not only spatial learning but also procedural learning. To determine if sleep is important for the consolidation of a single-trial, hippocampus-dependent task, we sleep deprived animals for 0-5 and 5-10 h after training for contextual and cued fear conditioning. We found that sleep deprivation from 0-5 h after training for this task impaired memory consolidation for contextual fear conditioning whereas sleep deprivation from 5-10 h after training had no effect. Sleep deprivation at either time point had no effect on cued fear conditioning, a hippocampus-independent task. Previous studies have determined that memory consolidation for fear conditioning is impaired when protein kinase A and protein synthesis inhibitors are administered at the same time as when sleep deprivation is effective, suggesting that sleep deprivation may act by modifying these molecular mechanisms of memory storage.