LACK OF AGE-DEPENDENT CISPLATIN NEPHROTOXICITY
LACK OF AGE-DEPENDENT CISPLATIN NEPHROTOXICITY
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DOI：
10.1016/0002-9343(84)90280-8
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发表时间：
1984-01-01
影响因子：
5.9
通讯作者：
KENNEDY, BJ
中科院分区：
文献类型：
--
作者：
HRUSHESKY, WJM;SHIMP, W;KENNEDY, BJ
通过对 43 名接受 60 mg/m2 每月输注 295 次药物的患者进行连续治疗前和治疗后 24 小时肌酐清除率测定来评估顺铂肾毒性。使用积极的标准水合方案，不使用利尿剂。在这些患者中，14 人只有一个肾脏。与具有两个功能正常的肾脏的年轻人相比，老年患者和具有单个肾脏的患者治疗前肌酐清除率较低。有两个肾脏的老年和年轻患者的肾功能均出现相同的、进行性的、与剂量相关的恶化。单肾患者的肾功能并未下降，但双肾患者的肾功能下降明显。当以 60 mg/m2 顺铂给药时，由于年龄增长或继发于手术损失或 1 个肾脏输尿管完全梗阻继发的肾功能下降，不表明需要调整剂量或给药方案。
Cisplatin nephrotoxicity was evaluated by serial pretreatment and post-treatment 24-h creatinine clearance determinations in 43 patients who received 295 monthly infusions of 60 mg/m2 of this drug. An aggressive standard hydration protocol was used without diuretic administration. Of these patients, 14 had a single kidney. Older patients and patients with a single kidney had lower pretreatment creatinine clearances when compared with younger persons with 2 functioning kidneys. Older and younger patients with 2 kidneys had an equal, progressive, dose-related deterioration of renal function. Renal function did not decline in persons with a single kidney but did so markedly in those with 2 kidneys. When administered at 60 mg/m2 cisplatin dose or schedule modification is not indicated on the basis of advancing age or decreased renal function secondary to the surgical loss or total ureteral obstruction of 1 kidney.