Systematic review of the epidemiology of acne vulgaris
Systematic review of the epidemiology of acne vulgaris
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DOI：
10.1038/s41598-020-62715-3
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发表时间：
2020-04-01
影响因子：
4.6
通讯作者：
Chew, Fook Tim
中科院分区：
文献类型：
--
作者：
Heng, Anna Hwee Sing;Chew, Fook Tim
对从Web of Science搜索中获得的痤疮流行病学研究进行了系统综述，以研究与痤疮表现和严重程度相关的风险因素。在多项研究中，观察到几个风险因素-家族史，年龄，BMI和皮肤类型-与痤疮表现或严重程度之间存在很强的关联。超重/肥胖BMI与正常/体重不足BMI的合并比值比为2.36（95% CI 1.97-2.83），父母有家族史与父母无家族史的合并比值比为2.91（95% CI 2.58-3.28），证明了这种强相关性。此外，性别（男性相对于女性）的合并比值比为1.07（95% CI 0.42-2.71）。然而，其他因素（如饮食因素和吸烟）与痤疮表现或严重程度之间的关联不太清楚，研究之间的结果不一致。因此，需要进一步的研究来了解这些因素如何影响痤疮的发展和严重程度。这项研究总结了可能影响痤疮表现或严重痤疮风险的潜在因素，可以帮助研究人员和临床医生了解痤疮和严重痤疮的流行病学。此外，这些发现可以指导未来的痤疮研究，希望能够深入了解痤疮的病理生理学，从而开发有效的痤疮治疗方法。
A systematic review was conducted on epidemiology studies on acne obtained from a Web of Science search to study risk factors associated with acne presentation and severity. A strong association was observed between several risk factors - family history, age, BMI and skin type - and acne presentation or severity in multiple studies. The pooled odds ratio of 2.36 (95% CI 1.97-2.83) for overweight/obese BMI with reference to normal/underweight BMI and the pooled odds ratio of 2.91 (95% CI 2.58-3.28) for family history in parents with reference to no family history in parents demonstrate this strong association. In addition, a pooled odds ratio of 1.07 (95% CI 0.42-2.71) was obtained for sex (males with reference to females). However, the association between other factors, such as dietary factors and smoking, and acne presentation or severity was less clear, with inconsistent results between studies. Thus, further research is required to understand how these factors may influence the development and severity of acne. This study summarizes the potential factors that may affect the risk of acne presentation or severe acne and can help researchers and clinicians to understand the epidemiology of acne and severe acne. Furthermore, the findings can direct future acne research, with the hope of gaining insight into the pathophysiology of acne so as to develop effective acne treatments.