Slicing tRNAs to boost functional ncRNA diversity
Slicing tRNAs to boost functional ncRNA diversity
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DOI：
10.4161/rna.27177
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发表时间：
2013-12-01
期刊：
影响因子：
4.1
通讯作者：
Polacek, Norbert
中科院分区：
文献类型：
--
作者：
Gebetsberger, Jennifer;Polacek, Norbert
RNA分子转录后裂解产生更小的片段是一种广泛存在的机制，它扩大了细胞RNome的结构和功能的复杂性。这种RNA片断的底物既有编码蛋白质的RNA，也有编码蛋白质的RNA。特别是，来自前体和成熟tRNA的片段代表了快速增长的转录后RNA片段之一。重要的是，这些tRNA片段与它们的亲本tRNA分子相比，具有不同的表达模式、丰度、细胞定位或生物学作用。在这里，我们回顾了最近关于tRNA裂解的报道，并试图根据它们的来源和细胞功能对tRNA片段进行分类。TRNA衍生片段的生物学范围从翻译控制、RNA沉默到调控细胞凋亡，从而明显扩大了ncRNA生物学的功能谱系。
Post-transcriptional cleavage of RNA molecules to generate smaller fragments is a widespread mechanism that enlarges the structural and functional complexity of cellular RNomes. Substrates for such RNA fragmentations are coding as well as non-protein-coding RNAs. In particular, fragments derived from both precursor and mature tRNAs represent one of the rapidly growing classes of post-transcriptional RNA pieces. Importantly, these tRNA fragments possess distinct expression patterns, abundance, cellular localizations, or biological roles compared with their parental tRNA molecules. Here we review recent reports on tRNA cleavage and attempt to categorize tRNA pieces according to their origin and cellular function. The biological scope of tRNA-derived fragments ranges from translation control, over RNA silencing, to regulating apoptosis, and thus clearly enlarges the functional repertoire of ncRNA biology.