Ethanol-induced plasticity of GABAA receptors in the basolateral amygdala.
Ethanol-induced plasticity of GABAA receptors in the basolateral amygdala.
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DOI：
10.1007/s11064-014-1297-z
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发表时间：
2014-06
影响因子：
4.4
通讯作者：
Spigelman, Igor
中科院分区：
文献类型：
--
作者：
Lindemeyer, A. Kerstin;Liang, Jing;Marty, Vincent N.;Meyer, Edward M.;Suryanarayanan, Asha;Olsen, Richard W.;Spigelman, Igor
Acute and chronic ethanol (EtOH) administration is known to affect function, surface expression, and subunit composition of γ-aminobutyric acid (A) receptors (GABAARs) in different parts of the brain, which is believed to play a major role in alcohol dependence and withdrawal symptoms. The basolateral amygdala (BLA) participates in anxiety-like behaviors including those induced by alcohol withdrawal. In the present study we assessed the changes in cell surface levels of select GABAAR subunits in the BLA of a rat model of alcohol dependence induced by chronic intermittent EtOH (CIE) treatment and long-term (>40 days) withdrawal and investigated the time-course of such changes after a single dose of EtOH (5 g/kg, gavage). We found an early decrease in surface expression of α4 and γ subunits at 1 h following single dose EtOH treatment. At 48 h post-EtOH and after CIE treatment there was an increase in α4 and γ2, while α1, α2, and γ surface expression were decreased. To relate functional changes in GABAARs to changes in their subunit composition we analyzed miniature inhibitory postsynaptic currents (mIPSCs) and the picrotoxin-sensitive tonic current (Itonic) 48 h after EtOH intoxication. The Itonic magnitude and most of the mIPSC kinetic parameters (except faster mIPSC decay) were unchanged at 48 h post-EtOH. At the same time, Itonic potentiation by acute EtOH was greatly reduced, whereas mIPSCs became significantly more sensitive to potentiation by acute EtOH. These results suggest that EtOH intoxication-induced GABAAR plasticity in the BLA might contribute to the diminished sedative/hypnotic and maintained anxiolytic effectiveness of EtOH.
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影响因子：
2.9
作者：
McCool, BA;Frye, GD;Botting, SK
通讯作者：
Botting, SK
影响因子：
4.7
作者：
Kumar, S;Kralic, JE;Morrow, AL
通讯作者：
Morrow, AL
影响因子：
2.3
作者：
Laeck, A. K.;Christian, D. T.;McCool, B. A.
通讯作者：
McCool, B. A.
DOI：
10.1124/jpet.112.201954
发表时间：
2013-05-01
影响因子：
3.5
作者：
Carlson, Stephen L.;Kumar, Sandeep;Morrow, A. Leslie
通讯作者：
Morrow, A. Leslie
DOI：
10.1124/jpet.106.110890
发表时间：
2006-12-01
影响因子：
3.5
作者：
Kumar, S.;Lane, B. M.;Morrow, A. L.
通讯作者：
Morrow, A. L.