Human papillomavirus and invasive cervical cancer in Brazil.
Human papillomavirus and invasive cervical cancer in Brazil.
复制标题
DOI：
10.1038/bjc.1994.18
复制
发表时间：
1994-01
影响因子：
8.8
通讯作者：
Walboomers, J M
中科院分区：
文献类型：
--
作者：
Eluf-Neto, J;Booth, M;Munoz, N;Bosch, F X;Meijer, C J;Walboomers, J M
在巴西进行了一项以医院为基础的病例对照研究，以探讨人乳头瘤病毒（HPV）在浸润性宫颈癌发展中的作用。该研究包括199例组织学证实的事件病例和225例年龄频率匹配的对照，这些对照选自广泛的诊断类别。应用聚合酶链反应（PCR）技术检测刮片和刷片宫颈标本中的HPV DNA。84%的病例中检测到HPV DNA，而对照组为17%。HPV 16、18、31和33型的阳性率为66%，而对照组仅为6%。除HPV外，性伴侣数量、初次性交年龄、产次和口服避孕药使用时间与宫颈癌风险增加显著相关。既往巴氏涂片检查史与风险降低显著相关。调整后，只有HPV DNA的存在，奇偶性和以前的涂片史仍然是独立的危险因素。与HPV 16、18、31和33相关的宫颈癌的调整优势比为69.7（95%置信区间28.7-169.6），与未确定类型相关的宫颈癌的调整优势比为12.0（5.1-28.5）。这项研究中发现的非常高的风险进一步表明这种病毒与宫颈癌的病因有关。
A hospital-based case-control study was undertaken to examine the role of human papillomavirus (HPV) in the development of invasive cervical cancer in Brazil. The study included 199 histologically confirmed incident cases and 225 age-frequency-matched controls selected from a wide range of diagnostic categories. A polymerase chain reaction technique was used to detect HPV DNA in cervical specimens collected with spatula and brush. HPV DNA was detected in 84% of the cases compared with 17% of controls. Grouping HPV types 16, 18, 31 and 33, 66% of the cases were positive compared with only 6% of the controls. In addition to HPV, number of sexual partners, early age at first intercourse, parity and duration of oral contraceptive use were significantly associated with an increased risk of cervical cancer. A history of previous Papanicolaou smears was significantly associated with a decreased risk. After adjustment, only presence of HPV DNA, parity and history of previous smears remained as independent risk factors. The adjusted odds ratios of cervical cancer associated with HPV 16, 18, 31, and 33 was 69.7 (95% confidence interval 28.7-169.6) and with unidentified types was 12.0 (5.1-28.5). The very high risks found in this study further implicate this virus in the aetiology of cervical cancer.