Interruption of a basal ganglia-forebrain circuit prevents plasticity of learned vocalizations
Interruption of a basal ganglia-forebrain circuit prevents plasticity of learned vocalizations
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DOI：
10.1038/35008083
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发表时间：
2000-04-13
期刊：
影响因子：
64.8
通讯作者：
Doupe, AJ
中科院分区：
文献类型：
--
作者：
Brainard, MS;Doupe, AJ
鸟鸣声就像言语一样，是一种后天习得的发声行为，很大程度上依赖于听觉。在鸣禽（1）和人类（2）中，通过震耳欲聋的听觉反馈消除会导致成年声音产生逐渐恶化。在这里，我们研究了成年斑胸草雀维持鸣叫过程中听觉反馈处理的神经机制。我们证明，震耳欲聋的声音对歌曲产生的有害影响可以通过对神经系统的第二次损伤（基底神经节前脑回路的损伤）来预防。结果表明，消除听觉反馈会产生指导性信号，主动驱动歌曲的非适应性变化；他们还表明，这种指导性信号是在基底神经节-前脑通路内产生（或通过其传递）的。我们的研究结果提供了证据，表明皮质基底神经节回路可能在运动性能校准过程中参与感觉反馈的评估，并证明对此类回路的损坏对先前习得的行为几乎没有影响，同时明显破坏了适应性修改该行为的能力。
Birdsong, like speech, is a learned vocal behaviour that relies greatly on hearing; in both songbirds(1) and humans(2) the removal of auditory feedback by deafening leads to a gradual deterioration of adult vocal production. Here we investigate the neural mechanisms that contribute to the processing of auditory feedback during the maintenance of song in adult zebra finches. We show that the deleterious effects on song production that normally follow deafening can be prevented by a second insult to the nervous system-the lesion of a basal ganglia-forebrain circuit. The results suggest that the removal of auditory feedback leads to the generation of an instructive signal that actively drives nonadaptive changes in song; they also suggest that this instructive signal is generated within (or conveyed through) the basal ganglia-forebrain pathway. Our findings provide evidence that cortical-basal ganglia circuits may participate in the evaluation of sensory feedback during calibration of motor performance, and demonstrate that damage to such circuits can have little effect on previously learned behaviour while conspicuously disrupting the capacity to adaptively modify that behaviour.