Pharmacokinetics of Metformin during Pregnancy
Pharmacokinetics of Metformin during Pregnancy
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DOI：
10.1124/dmd.109.031245
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发表时间：
2010-05-01
影响因子：
3.9
通讯作者：
Hebert, Mary F.
中科院分区：
文献类型：
--
作者：
Eyal, Sara;Easterling, Thomas R.;Hebert, Mary F.
我们的目的是评估二甲双胍在妊娠期的药代动力学。在妊娠早期至晚期(n=35)和产后(n=16)接受二甲双胍治疗的妇女，在一个稳定的剂量间隔内采集了连续的血液和尿样。12名妇女在分娩时采集了母血和脐带血样本。还测定了6名妇女在一次给药间隔内获得的母乳样本中的二甲双胍浓度。妊娠中期(723±-243ml/min，P<；0.01)和晚期(625+/-130ml/min，P<；0.01)的二甲双胍肾清除率显著高于产后(477+/-132ml/min，P<；0.01)。这些变化反映了与产后相比，妊娠中期和晚期的内生肌酐清除量(240+/-70毫升/分，P<；0.01和207+/-56毫升/分，P<；0.05比165+/-44毫升/分)和二甲双胍净分泌清除量(480+/-190毫升/分，P<；0.01和419+/-78毫升/分，P<；0.01比313+/-98毫升/分)显著增加。分娩时脐带血浆中的二甲双胍浓度在无法检测到的(
Our objective was to evaluate the pharmacokinetics of metformin during pregnancy. Serial blood and urine samples were collected over one steady-state dosing interval in women treated with metformin during early to late pregnancy (n = 35) and postpartum (n = 16). Maternal and umbilical cord blood samples were obtained at delivery from 12 women. Metformin concentrations were also determined in breast milk samples obtained over one dosing interval in 6 women. Metformin renal clearance increased significantly in mid (723 +/- 243 ml/min, P < 0.01) and late pregnancy (625 +/- 130 ml/min, P < 0.01) compared with postpartum (477 +/- 132 ml/min). These changes reflected significant increases in creatinine clearance (240 +/- 70 ml/min, P < 0.01 and 207 +/- 56 ml/min, P < 0.05 versus 165 +/- 44 ml/min) and in metformin net secretion clearance (480 +/- 190 ml/min, P < 0.01 and 419 +/- 78 ml/min, P < 0.01 versus 313 +/- 98 ml/min) in mid and late pregnancy versus postpartum, respectively. Metformin concentrations at the time of delivery in umbilical cord plasma ranged between nondetectable (