Unilateral Nasal Obstruction during Later Growth Periods Affects Craniofacial Muscles in Rats.
Unilateral Nasal Obstruction during Later Growth Periods Affects Craniofacial Muscles in Rats.
复制标题
晚期生长期间的单侧鼻阻塞会影响大鼠的颅面肌肉。
DOI：
10.3389/fphys.2016.00669
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发表时间：
2016
影响因子：
4
通讯作者：
Ono T
中科院分区：
文献类型：
--
作者：
Uchima Koecklin KH;Hiranuma M;Kato C;Funaki Y;Kataguchi T;Yabushita T;Kokai S;Ono T
鼻塞可以发生在不同的人生阶段。在生命的早期阶段，呼吸系统仍处于发育阶段，在生长期成熟。先前的研究表明，新生大鼠鼻塞会改变颅面功能。然而，对于生长后期鼻塞的影响，我们知之甚少。本研究的目的是探讨生长后期鼻塞对开颚反射（JOR）和伸舌肌功能特征的影响。102只6日龄雄性Wistar大鼠随机分为对照组和实验组（均为51只）。为了确定适当的鼻塞时间，在第8天，对照组在第3、5、7、9和11周监测动脉血氧饱和度（SpO2）。实验组大鼠在5周龄时进行单侧鼻塞治疗。实验组于第7、9、11周监测SpO2。在7周、9周和11周时记录JOR的肌电反应和舌突肌的收缩特性。对照组SpO2下降至5周龄，保持相对稳定至11周龄。实验组的SpO2明显低于对照组。在实验组中，JOR的变化包括更长的潜伏期和更小的峰间振幅，而舌突肌的收缩特性的变化包括更大的抽搐和破伤风力，以及更长的半衰减时间。这些结果提示生长后期鼻塞可能影响颅面功能。
Nasal obstruction can occur at different life stages. In early stages of life the respiratory system is still under development, maturing during the growth period. Previous studies have shown that nasal obstruction in neonatal rats alters craniofacial function. However, little is known about the effects of nasal obstruction that develops during later growth periods. The aim of this study was to investigate the effects of nasal obstruction during later periods of growth on the functional characteristics of the jaw-opening reflex (JOR) and tongue-protruding muscles. In total, 102 6-day-old male Wistar rats were randomized into either a control or experimental group (both n = 51). In order to determine the appropriate timing of nasal obstruction, the saturation of arterial oxygen (SpO2) was monitored at 8 days, and at 3, 5, 7, 9, and 11 weeks in the control group. Rats in the experimental group underwent unilateral nasal obstruction at the age of 5 weeks. The SpO2 was monitored at 7, 9, and 11 weeks in the experimental group. The electromyographic responses of JOR and the contractile properties of the tongue-protruding muscles were recorded at 7, 9, and 11 weeks. In the control group, SpO2 decreased until 5 weeks of age, and remained relatively stable until 11 weeks of age. The SpO2 was significantly lower in the experimental group than in the control. In the experimental group, JOR changes included a longer latency and smaller peak-to-peak amplitude, while changes in the contractile properties of the tongue-protruding muscles included larger twitch and tetanic forces, and a longer half-decay time. These results suggest that nasal obstruction during later growth periods may affect craniofacial function.