Anatomy and physiology of saccadic long-lead burst neurons recorded in the alert squirrel monkey. I. Descending projections from the mesencephalon.
Anatomy and physiology of saccadic long-lead burst neurons recorded in the alert squirrel monkey. I. Descending projections from the mesencephalon.
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警觉松鼠猴中记录的扫视长导爆神经元的解剖学和生理学。
DOI：
10.1152/jn.1996.76.1.332
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Highstein,SM
中科院分区：
文献类型：
--
作者：
Scudder,CA;Moschovakis,AK;Karabelas,AB;Highstein,SM
1.采用轴突内记录和辣根过氧化物酶注射技术，结合自发性眼动监测，对警觉猴中脑眼跳相关长导联爆发神经元（LLBN）的放电模式和轴突投射进行了研究。2.大多数恢复的轴突（N = 21）属于两类神经元。大多数（N = 13）被确定为传出的上级丘和有限的运动领域典型的丘扫视相关的爆发神经元。这种放电模式，它们对一个或两个上级丘的电刺激的反应，以及它们的形态学外观确定它们为顶盖传出神经元的T类成员。3.这些T细胞的轴突在几个与扫视相关的脑干区域内部署了终末区域，包括投射到小脑的脑桥被盖网状核;脑桥口侧和尾侧网状核，其中包含兴奋性运动前爆发神经元;中缝中间核，其中包含全间歇神经元;含有抑制性运动前爆发神经元的旁巨细胞核，以及脑干网状结构的其他分化程度较低的部分。4.另一类LLBN（N = 4）的胞体位于Cajal间质核外侧的髓质网状结构中。它们主要投射到中缝核、延髓网状结构和旁正中网状核。放电为方向型，具有向上ON方向（N = 3）和向下ON方向（N = 1）。5.投射到脑桥和延髓眼神经结构但其胞体未恢复的其他纤维（N = 4）说明也存在其他类型的LLBN，其有助于扫视眼球运动的产生和控制。6.我们的研究结果补充了以前的数据T型上级丘传出轴突的轨迹。他们还证明存在LLBN位于中脑网状结构和其在脑干中的目标区域。这些研究结果的影响，目前的概念，oculptoms控制进行了讨论。
1. The intra-axonal recording and horseradish peroxidase injection technique together with spontaneous eye movement monitoring has been employed in alert behaving monkeys to study the discharge pattern and axonal projections of mesencephalic saccade-related long-lead burst neurons (LLBNs). 2. Most of the recovered axons (N = 21) belonged to two classes of neurons. The majority (N = 13) were identified as efferents of the superior colliculus and had circumscribed movement fields typical of collicular saccade-related burst neurons. This discharge pattern, their responses to electrical stimulation of one or both superior colliculi, and their morphological appearance identified them as members of the T class of tectal efferent neurons. 3. Axons of these T cells deployed terminal fields within several saccade-related brain stem areas including the nucleus reticularis tegmenti pontis, which projects to the cerebellum; the nucleus reticularis pontis oralis and caudalis, which contains excitatory premotor burst neurons; the nucleus raphe interpositus, which contains omnipause neurons; the nucleus paragigantocellularis, which contains inhibitory premotor burst neurons, as well as other less differentiated parts of the brain stem reticular formation. 4. The other class of LLBNs (N = 4) had their somata in the medullary reticular formation just lateral to the interstitial nucleus of Cajal. They projected primarily to the raphe nuclei, the medullary reticular formation, and the paramedian reticular nucleus. Discharges were of the directional type with up ON directions (N = 3) and down ON directions (N = 1). 5. Other fibers, which project to pontine and medullary oculomotor structures but whose somata were not recovered (N = 4), illustrate that there are also other types of LLBNs that contribute to the generation and control of saccadic eye movements. 6. Our findings complement previous data about the axonal trajectories of T-type superior colliculus efferents. They also demonstrate the existence of LLBNs located in the mesencephalic reticular formation and their target areas in the brain stem. Implications of these findings for current concepts of oculomotor control are discussed.