EVIDENCE THAT THE SUBSTANTIA NIGRA IS A COMPONENT OF THE ENDOGENOUS PAIN SUPPRESSION SYSTEM IN THE RAT
EVIDENCE THAT THE SUBSTANTIA NIGRA IS A COMPONENT OF THE ENDOGENOUS PAIN SUPPRESSION SYSTEM IN THE RAT
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DOI：
10.1016/0006-8993(88)90971-7
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发表时间：
1988-04-26
期刊：
影响因子：
2.9
通讯作者：
GUILLORY, EC
中科院分区：
文献类型：
--
作者：
BAUMEISTER, AA;ANTICICH, TG;GUILLORY, EC
本研究试图确定黑质中的阿片受体是否可能介导由全身性吗啡产生的抗伤害感受。双侧黑质内微量注射盐酸纳洛酮(0.3-10微克)可抑制全身注射硫酸吗啡(5 mg/kg，S.C.)的抗伤害性效应。在甩尾和热板试验中以与剂量相关的方式进行。腹侧被盖区注射纳洛酮(3微克)不能改变全身吗啡(5 mg/kg，S.C.)产生的抗伤害性感觉。这些发现支持这样一种观点，即黑质是内源性疼痛抑制系统的重要组成部分，但以前没有被认识到。
The present study sought to determine whether opiate receptors in the substantia nigra may mediate antinociception produced by systemic morphine. Bilateral intranigral microinjection of naloxone-HCl (0.3-10 .mu.g) suppressed the antinociceptive effects of systemically administered morphine sulfate (5 mg/kg, s.c.) on the tail-flick and hot-plate tests in a dose-related manner. Injection of naloxone (3 .mu.g) into the ventral tegmental area did not alter antinociception produced by systemic morphine (5 mg/kg, s.c.). These findings support the argument that the substantia nigra is an essential, and previously unrecognized, component of the endogenous pain suppression system.