Characterization of Culex Flavivirus (Flaviviridae) strains isolated from mosquitoes in the United States and Trinidad
Characterization of Culex Flavivirus (Flaviviridae) strains isolated from mosquitoes in the United States and Trinidad
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DOI：
10.1016/j.virol.2008.12.034
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发表时间：
2009-03-30
期刊：
影响因子：
3.7
通讯作者：
Tesh, Robert B.
中科院分区：
文献类型：
--
作者：
Kim, Dal Y.;Guzman, Hilda;Tesh, Robert B.
最近的报道表明，类似于细胞融合剂病毒（CFAV）的黄病毒自然感染多种蚊子物种。这些新识别的昆虫特异性病毒在黄病毒属内包含不同的CFAV复合物。在这里，我们描述了9株库蚊黄病毒（Cx FV），CFAV复合体的成员，收集在美国（东德克萨斯州）和特立尼达的蚊子的分离和表征。这9个蚊子分离株的包膜蛋白基因序列与GenBank中其他CFAV复合体黄病毒的序列的系统发育分析表明，美国分离株与亚洲（日本和印度尼西亚）的CxFV分离株分组，而特立尼达分离株与中美洲的CxFV分离株更相似。下面讨论CFAV复合体黄病毒可能的生物学意义。(c)2009 Elsevier Inc. All rights reserved.
Recent reports indicate that flaviviruses similar to the cell fusing agent virus (CFAV) naturally infect a wide variety of mosquito species. These newly recognized insect-specific viruses comprise a distinct CFAV complex within the genus Flavivirus. Here, we describe the isolation and characterization of nine strains of Culex flavivirus (Cx FV), a member of the CFAV complex, from mosquitoes collected in the United States (East Texas) and Trinidad. Phylogenetic analyses of the envelope protein gene sequences of these nine mosquito isolates with those of other CFAV complex flaviviruses in GenBank indicate that the U.S. isolates group with CxFV isolates from Asia (Japan and Indonesia), while the Trinidad isolates are more similar to CxFV isolates from Central America. A discussion follows on the possible biological significance of the CFAV complex flaviviruses. (c) 2009 Elsevier Inc. All rights reserved.