A comparison of pressure-volume relations of the fetal, newborn, and adult heart.
A comparison of pressure-volume relations of the fetal, newborn, and adult heart.
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胎儿、新生儿和成人心脏压力-容积关系的比较。
DOI：
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发表时间：
1972
影响因子：
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通讯作者：
W. Friedman
中科院分区：
文献类型：
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作者：
T. Romero;J. Covell;W. Friedman
罗梅罗、托马斯、詹姆斯·科维尔和威廉·F·弗里德曼。胎儿、新生儿和成人心脏压力-容量关系的比较。上午好。J.Physiol.222(5)：1285-L 290。1972年--关于发育中的心脏的生理特征的信息明显缺乏。本文对8只胎羊、9只新生羔羊和10只成年绵羊的左、右心顺应性进行了分析和比较。此外，为了评估对侧脑室充盈对扩张性的影响，在对侧脑室排空的情况下和在不同的固定压力下测定每个脑室的扩张性。使用不同的左、右室几何模型，压力-容量数据被转换为室壁张力和内径变化百分比的单位，从而可以直接比较所有研究的年龄组。此外，通过测定脑室羟脯氨酸的浓度来评估结缔组织对各年龄段顺应性的贡献。本研究的主要发现表明，近足月胎羊左、右心室的压力-体积和室壁张力-半径关系是相似的。在新生儿期，右室具有与胎儿右室相似的顺应性特征。成人右心室的顺应性明显高于胎儿和新生儿。在出生后早期，左心室改变了其压力-体积和应力-应变特性，并处于胎儿和成人之间的中间位置。在所有年龄段，右心室比左心室顺应性更强。当人们评估充盈一个脑室对降低对侧脑室扩张性的影响时，最深刻的影响是在胎儿中观察到的，其次是新生儿，然后是成年人。
ROMERO, TOMAS, JAMES COVELL, AND WILLIAM F. FRIEDMAN. A comparison of pressure-volume relations of the fetal, newborn, and adult heart. Am. J. Physiol. 222(5) : 1285-l 290. 1972.-A marked paucity of information exists concerning the physiological characteristics of the developing heart. The purpose of the present investigation was to analyze and compare the compliance of the right and left ventricles in hearts obtained from 8 fetal and 9 newborn lambs and 10 adult sheep. Moreover, to assess the influence of filling of the contralateral chamber on distensibility, the distensibility of each ventricle was determined both with the opposite ventricle empty and at various fixed pressures. Using various models of left and right ventricular geometry, the pressure-volume data were converted to units of wall tension and percentage change in internal radius, allowing a direct comparison of all of the age groups studied. In addition, the concentrations of ventricular hydroxyproline were determined to evaluate the contribution of connective tissue to compliance at each age level. The major findings of the present study indicate that the pressure-volume and wall tension-radius relations of both the left and right ventricles are comparable in the fetal lamb close to term. In the newborn period, the right ventricle has compliance characteristics similar to the right ventricle of the fetus. The adult right ventricle is significantly more compliant than both the fetus and newborn. In the early postnatal period, the left ventricle alters its pressurevolume and stress-strain characteristics and assumes an intermediate position between fetus and adult. At all ages the right ventricle is more compliant than the left ventricle. When one evaluates the influence of filling one ventricle on reducing the distensibility of the opposite ventricle, the most profound effect is observed in the fetus, followed by the newborn, and then the adult.